Analysis of cyclin-dependent kinase inhibitor 1B mutation in Han Chinese women with premature ovarian failure

被引：8
|
作者：
Wang, Binbin [2 ,3 ]
Ni, Feng [1 ]
Li, Lin [2 ,4 ]
Wei, Zhaolian [1 ]
Zhu, Xianglong [4 ]
Wang, Jing [2 ,3 ]
Cao, Yunxia [1 ]
Ma, Xu [2 ,3 ,5 ]
机构：
[1] Anhui Med Univ, Affiliated Hosp 1, Reprod Med Ctr, Hefei, Peoples R China
[2] Natl Res Inst Family Planning, Beijing 100081, Peoples R China
[3] Peking Union Med Coll, Grad Sch, Beijing 100021, Peoples R China
[4] China Agr Univ, Coll Biol Sci, Beijing 100094, Peoples R China
[5] WHO, Collaborating Ctr Res Human Reprod, Beijing, Peoples R China
来源：
REPRODUCTIVE BIOMEDICINE ONLINE | 2010年 / 21卷 / 02期
关键词：
CDKN1B; P27; premature ovarian failure (POF); variant; PHOSPHOINOSITIDE 3-KINASE PATHWAY; FOLLICULAR DEVELOPMENT; MICE; DYSFUNCTION; ACTIVATION; GROWTH; CANCER; FOXO3A; GENE;
D O I：
10.1016/j.rbmo.2010.04.025
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The gene for cyclin-dependent kinase inhibitor 1B (CDKN1B; also known as P27(KIP1) and P27) encodes a cyclin-dependent kinase inhibitor and controls ovarian development in mice. In p27-deficient (p27(-/-)) mice, the overactivated follicular pool in ovaries was largely depleted, causing premature ovarian failure. The goal of this research was to investigate whether there are nucleotide changes in the CDKN1B gene of Han Chinese women with premature ovarian failure, as compared with control volunteers using candidate gene sequencing. No novel variations were found in exons encoding for CDKN1B. So the mutations in CDKN1B are not common with premature ovarian failure in Han Chinese women. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：212 / 214
页数：3
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