DELAWANID FOR THE TREATMENT OF PULMONARY MULTIDRUG-RESISTANT TUBERCULOSIS

被引：13
作者：
Thakare, R. [1 ]
Soni, I. [1 ]
Dasgupta, A. [1 ]
Chopra, S. [1 ]
机构：
[1] CSIR Cent Drug Res Inst, Div Microbiol, Lucknow 226031, Uttar Pradesh, India
来源：
DRUGS OF TODAY | 2015年 / 51卷 / 02期
关键词：
Delamanid; Nitro-dihydro-imidazole derivative; MDR-TB; Tuberculosis; Antimycobacterial; BACTERICIDAL ACTIVITY; DELAMANID; OPC-67683;
D O I：
10.1358/dot.2015.51.2.2245645
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Out of a handful of new drugs currently in clinical trials for the treatment of tuberculosis, delamanid, a nitro-dihydroimidazole derivative, has successfully emerged. Delamanid is a novel mycolic acid biosynthesis inhibitor that is equally potent against drug-sensitive as well as drug-resistant Mycobacterium tuberculosis. One of the strongest points for delamanid is its inability to be metabolized by cytochrome P450 enzymes, making it a promising candidate to be used in combination therapies for the treatment of tuberculosis and HIV Additionally, it has successfully completed phase II efficacy trials and has received conditional marketing authorization from the European Medicines Agency.
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收藏
页码：117 / 123
页数：7
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