IL-17 receptor-based signaling and implications for disease

被引：450

作者：

Li, Xiaoxia ^{[1
]}

Bechara, Rami ^{[2
]}

Zhao, Junjie ^{[1
]}

McGeachy, Mandy J. ^{[2
]}

Gaffen, Sarah L. ^{[2
]}

机构：

[1] Cleveland Clin, Lerner Res Inst, Dept Inflammat & Immun, Cleveland, OH 44106 USA

[2] Univ Pittsburgh, Div Rheumatol & Clin Immunol, Pittsburgh, PA 15260 USA

来源：

NATURE IMMUNOLOGY | 2019年 / 20卷 / 12期

基金：

美国国家卫生研究院;

关键词：

KAPPA-B-ZETA; NECROSIS-FACTOR-ALPHA; MESSENGER-RNA; T-CELL; KERATINOCYTE PROLIFERATION; INTERLEUKIN-17; RECEPTOR; AUTOIMMUNE INFLAMMATION; NEGATIVE REGULATION; ADAPTER PROTEIN; INBORN-ERRORS;

D O I：

10.1038/s41590-019-0514-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes, including host defense, tissue repair, the pathogenesis of inflammatory disease and the progression of cancer. In contrast to its profound impact in vivo, IL-17 exhibits surprisingly moderate activity in cell-culture models, which presents a major knowledge gap about the molecular mechanisms of IL-17 signaling. Emerging studies are revealing a new dimension of complexity in the IL-17 pathway that may help explain its potent and diverse in vivo functions. Discoveries of new mRNA stabilizers and receptor-directed mRNA metabolism have provided insights into the means by which IL-17 cooperates functionally with other stimuli in driving inflammation, whether beneficial or destructive. The integration of IL-17 with growth-receptor signaling in specific cell types offers new understanding of the mitogenic effect of IL-17 on tissue repair and cancer. This Review summarizes new developments in IL-17 signaling and their pathophysiological implications.

引用

页码：1594 / 1602

页数：9

共 120 条

[1] Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells [J].

Acosta-Rodriguez, Eva V. ;

Rivino, Laura ;

Geginat, Jens ;

Jarrossay, David ;

Gattorno, Marco ;

Lanzavecchia, Antonio ;

Sallusto, Federica ;

Napolitani, Giorgio .

NATURE IMMUNOLOGY, 2007, 8 (06) :639-646

[2] Increased IL-17A secretion in response to Candida albicans in autoimmune polyendocrine syndrome type 1 and its animal model [J].

Ahlgren, Kerstin M. ;

Moretti, Silvia ;

Lundgren, Brita Ardesjo ;

Karlsson, Iulia ;

Ahlin, Erik ;

Norling, Anna ;

Hallgren, Asa ;

Perheentupa, Jaakko ;

Gustafsson, Jan ;

Rorsman, Fredrik ;

Crewther, Pauline E. ;

Ronnelid, Johan ;

Bensing, Sophie ;

Scott, Hamish S. ;

Kampe, Olle ;

Romani, Luigina ;

Lobell, Anna .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2011, 41 (01) :235-245

[3] IL-17 integrates multiple self-reinforcing, feed-forward mechanisms through the RNA binding protein Arid5a [J].

Amatya, Nilesh ;

Childs, Erin E. ;

Cruz, J. Agustin ;

Aggor, Felix E. Y. ;

Garg, Abhishek V. ;

Berman, Andrea J. ;

Gudjonsson, Johann E. ;

Atasoy, Ulus ;

Gaffen, Sarah L. .

SCIENCE SIGNALING, 2018, 11 (551)

[4] IL-17 Signaling: The Yin and the Yang [J].

Amatya, Nilesh ;

Garg, Abhishek V. ;

Gaffen, Sarah L. .

TRENDS IN IMMUNOLOGY, 2017, 38 (05) :310-322

[5] Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans [J].

Bacher, Petra ;

Hohnstein, Thordis ;

Beerbaum, Eva ;

Roecker, Marie ;

Blango, Matthew G. ;

Kaufmann, Svenja ;

Roehmel, Jobst ;

Eschenhagen, Patience ;

Grehn, Claudia ;

Seidel, Kathrin ;

Rickerts, Volker ;

Lozza, Laura ;

Stervbo, Ulrik ;

Nienen, Mikalai ;

Babel, Nina ;

Milleck, Julia ;

Assenmacher, Mario ;

Cornely, Oliver A. ;

Ziegler, Maren ;

Wisplinghoff, Hilmar ;

Heine, Guido ;

Worm, Margitta ;

Siegmund, Britta ;

Maul, Jochen ;

Creutz, Petra ;

Tabeling, Christoph ;

Ruwwe-Gloesenkamp, Christoph ;

Sander, Leif E. ;

Knosalla, Christoph ;

Brunke, Sascha ;

Hube, Bernhard ;

Kniemeyer, Olaf ;

Brakhage, Axel A. ;

Schwarz, Carsten ;

Scheffold, Alexander .

CELL, 2019, 176 (06) :1340-+

[6] An ACT1 Mutation Selectively Abolishes Interleukin-17 Responses in Humans with Chronic Mucocutaneous Candidiasis [J].

Boisson, Bertrand ;

Wang, Chenhui ;

Pedergnana, Vincent ;

Wu, Ling ;

Cypowyj, Sophie ;

Rybojad, Michel ;

Belkadi, Aziz ;

Picard, Capucine ;

Abel, Laurent ;

Fieschi, Claire ;

Puel, Anne ;

Li, Xiaoxia ;

Casanova, Jean-Laurent .

IMMUNITY, 2013, 39 (04) :676-686

[7] IL17 factors are early regulators in the gut epithelium during inflammatory response to Vibrio in the sea urchin larva [J].

Buckley, Katherine M. ;

Ho, Eric Chun Hei ;

Hibino, Taku ;

Schrankel, Catherine S. ;

Schuh, Nicholas W. ;

Wang, Guizhi ;

Rast, Jonathan P. .

ELIFE, 2017, 6

[8] The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation [J].

Bulek, Katarzyna ;

Liu, Caini ;

Swaidani, Shadi ;

Wang, Liwen ;

Page, Richard C. ;

Gulen, Muhammet F. ;

Herjan, Tomasz ;

Abbadi, Amina ;

Qian, Wen ;

Sun, Dongxu ;

Lauer, Mark ;

Hascall, Vincent ;

Misra, Saurav ;

Chance, Mark ;

Aronica, Mark ;

Hamilton, Thomas ;

Li, Xiaoxia .

NATURE IMMUNOLOGY, 2011, 12 (09) :844-U61

[9] TRAF4 binds to the juxtamembrane region of EGFR directly and promotes kinase activation [J].

Cai, Gang ;

Zhu, Liang ;

Chen, Xing ;

Sun, Kevin ;

Li, Caini ;

Sen, Ganes C. ;

Stark, George R. ;

Qi, Jun ;

Li, Xiaoxia .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (45) :11531-11536

[10] Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression [J].

Calcinotto, Arianna ;

Brevi, Arianna ;

Chesi, Marta ;

Ferrarese, Roberto ;

Perez, Laura Garcia ;

Grioni, Matteo ;

Kumar, Shaji ;

Garbitt, Victoria M. ;

Sharik, Meaghen E. ;

Henderson, Kimberly J. ;

Tonon, Giovanni ;

Tomura, Michio ;

Miwa, Yoshihiro ;

Esplugues, Enric ;

Flavell, Richard A. ;

Huber, Samuel ;

Canducci, Filippo ;

Rajkumar, Vincent S. ;

Bergsagel, P. Leif ;

Bellone, Matteo .

NATURE COMMUNICATIONS, 2018, 9

← 1 2 3 4 5 6 7 8 9 10 →