Bioactivity of phenolic acids: Metabolites versus parent compounds: A review

被引：587

作者：

Heleno, Sandrina A. ^{[1
,2
]}

Martins, Anabela ^{[1
]}

Queiroz, Maria Joao R. P. ^{[2
]}

Ferreira, Isabel C. F. R. ^{[1
]}

机构：

[1] Escola Super Agr, Ctr Invest Montanha, P-5301854 Braganca, Portugal

[2] Univ Minho, Ctr Quim, P-4710057 Braga, Portugal

来源：

FOOD CHEMISTRY | 2015年 / 173卷

关键词：

Mushrooms; Phenolic acids; Biosynthesis/bioavailability; Metabolites; Chemical/enzymatic synthesis; Bioactivity; COPRINOPSIS-ATRAMENTARIA EXTRACT; ANTIOXIDANT ACTIVITY; ORGANIC-ACIDS; PROTOCATECHUIC ACID; CHLOROGENIC ACID; HUMAN PLASMA; GALLIC ACID; DIETARY POLYPHENOLS; LIPID-PEROXIDATION; ACYL GLUCURONIDES;

D O I：

10.1016/j.foodchem.2014.10.057

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phenolic acids are present in our diet in different foods, for example mushrooms. Due to their bioactive properties, phenolic acids are extensively studied and there is evidence of their role in disease prevention. Nevertheless, in vivo, these compounds are metabolized and circulate in the organism as glucuronated, sulphated and methylated metabolites, displaying higher or lower bioactivities. To clarify the importance of the metabolism of phenolic acids, knowledge about the bioactivity of metabolites is extremely important. In this review, chemical features, biosynthesis and bioavailability of phenolic acids are discussed, as well as the chemical and enzymatic synthesis of their metabolites. Finally, metabolite bioactive properties are compared with that of the corresponding parental compounds. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：501 / 513

页数：13

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