Additional aberrations of the ETV6 and RUNX1 genes have no prognostic impact in 229 t(12;21)(p13;q22)-positive B-cell precursor acute lymphoblastic leukaemias treated according to the NOPHO-ALL-2000 protocol

被引：4

作者：

Barbany, Gisela ^{[1
]}

Andersen, Mette K. ^{[2
]}

Autio, Kirsti ^{[3
]}

Borgstrom, Georg ^{[3
]}

Franco, Lucia Cavalier ^{[4
]}

Golovleva, Irina ^{[5
]}

Heim, Sverre ^{[6
,7
]}

Heinonen, Kristina ^{[8
]}

Hovland, Randi ^{[9
]}

Johansson, Bertil ^{[10
]}

Johannsson, Johann H. ^{[11
]}

Kjeldsen, Eigil ^{[12
]}

Nordgren, Ann

Palmqvist, Lars ^{[13
]}

Forestier, Erik ^{[14
]}

机构：

[1] Karolinska Inst, CMM, Dept Mol Med & Surg, S-17176 Stockholm, Sweden

[2] Rigshosp, Dept Clin Genet, Copenhagen, Denmark

[3] Univ Helsinki, Haartman Inst, Dept Pathol & Clin Genet, FIN-00014 Helsinki, Finland

[4] Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden

[5] Umea Univ Hosp, Dept Med Biosci Med & Clin Genet, Umea, Sweden

[6] Oslo Univ Hosp, Radiumhosp, Inst Med Informat, Sect Canc Cytogenet, Oslo, Norway

[7] Univ Oslo, Oslo, Norway

[8] Kuopio Univ Hosp, Chromosome & DNA Lab, Kuopio, Finland

[9] Haukeland Hosp, Ctr Med Genet & Mol Med, Bergen, Norway

[10] Lund Univ, Skane Univ Hosp, Univ & Reg Labs, Dept Clin Genet, Lund, Sweden

[11] Univ Hosp, Dept Clin Genet & Cytogenet, Reykjavik, Iceland

[12] Arhus Univ Hosp, Dept Hematol, Canc Cytogenet Lab, Aarhus, Denmark

[13] Sahlgrens Univ Hosp, Dept Clin Chem & Transfus Med, Gothemburg, Sweden

[14] Umea Univ, Dept Clin Sci, Umea, Sweden

来源：

LEUKEMIA RESEARCH | 2012年 / 36卷 / 07期

关键词：

FUSION;

D O I：

10.1016/j.leukres.2012.03.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：936 / 938

页数：3

共 8 条

[1] Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia:: an interphase FISH analysis [J].

Attarbaschi, A ;

Mann, G ;

König, M ;

Dworzak, MN ;

Trebo, MM ;

Mühlegger, N ;

Gadner, H ;

Haas, OA .

LEUKEMIA, 2004, 18 (10) :1611-1616

[2] Outcome of ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia in the NOPHO-ALL-1992 protocol:: frequent late relapses but good overall survival [J].

Forestier, Erik ;

Heyman, Mats ;

Andersen, Mette K. ;

Autio, Kirsi ;

Blennow, Elisabeth ;

Borgstrom, Georg ;

Golovleva, Irina ;

Heim, Sverre ;

Heinonen, Kristina ;

Hovland, Randi ;

Johannsson, Johann H. ;

Kerndrup, Gitte ;

Nordgren, Ann ;

Rosenquist, Richard ;

Swolin, Birgitta ;

Johansson, Bertil .

BRITISH JOURNAL OF HAEMATOLOGY, 2008, 140 (06) :665-672

[3] Incidence of TEL/AML1 fusion gene analyzed consecutively in children with acute lymphoblastic leukemia in relapse [J].

Harbott, J ;

Viehmann, S ;

Borkhardt, A ;

Henze, G ;

Lampert, F .

BLOOD, 1997, 90 (12) :4933-4937

[4] Native ETV6 deletions accompanied by ETV6-RUNX1 rearrangements are associated with a favourable prognosis in childhood acute lymphoblastic leukaemia: a candidate for prognostic marker [J].

Ko, Dae-Hyun ;

Jeon, Yongbum ;

Kang, Hyoung Jin ;

Park, Kyung Duk ;

Shin, Hee Young ;

Kim, Hyun Kyung ;

Cho, Han-Ik ;

Ahn, Hyo Seop ;

Lee, Dong Soon .

BRITISH JOURNAL OF HAEMATOLOGY, 2011, 155 (04) :530-533

[5]

Moorman AV, 2008, BLOOD, V112, P430

[6] Interphase FISH on TEL/AML1 positive acute lymphoblastic leukemia relapses - analysis of clinical relevance of additional TEL and AML1 copy number changes [J].

Peter, Anita ;

Heiden, Thomas ;

Taube, Tillmann ;

Koerner, Gabriele ;

Seeger, Karl .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2009, 83 (05) :420-432

[7] TEL-AML1 fusion in relapsed childhood acute lymphoblastic leukemia [J].

Seeger, K ;

Buchwald, D ;

Peter, A ;

Taube, T ;

von Stackelbere, A ;

Schmitt, G ;

Henze, G .

BLOOD, 1999, 94 (01) :374-375

[8] Incidence of additional genetic changes in the TEL and AML1 genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensitivity and clinical outcome [J].

Stams, WAG ;

Beverloo, HB ;

den Boer, M ;

de Menezes, R ;

Stigter, R ;

van Drunen, E ;

Ramakers-Van- oerden, NL ;

Loonen, AH ;

van Wering, ER ;

Janka-Schaub, G ;

Pieters, R .

LEUKEMIA, 2006, 20 (03) :410-416

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