Tetraphenylborate Salt of Atropine®: Synthesis and X-ray Structure of Tetraphenyl-λ4-borane, (1R,3r,5S,8s)-3-((3-Hydroxy-2-phenylpropanoyl)oxy)-8-methyl-8-azabicyclo[3.2.1]octan-8-ium Salt

被引：2

作者：

Mostafa, G. A. E. ^{[1
,2
]}

Ghabbour, H. A. ^{[1
,3
]}

Abdel-Aziz, H. A. ^{[1
,2
]}

机构：

[1] King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, POB 2457, Riyadh 11451, Saudi Arabia

[2] Natl Res Ctr, Dept Appl Organ Chem, Cairo 12622, Egypt

[3] Mansoura Univ, Dept Med Chem, Fac Pharm, Mansoura 35516, Egypt

来源：

CRYSTALLOGRAPHY REPORTS | 2017年 / 62卷 / 07期

关键词：

ION-SELECTIVE ELECTRODE; SODIUM TETRAPHENYLBORATE; ORGANIC CATIONS; TITRATION; SULFATE; DIPHENHYDRAMINE;

D O I：

10.1134/S1063774517070203

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The title compound, tetraphenylborate salt of atropine (RS)-(8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate tetraphenylborate salt, was prepared by the reaction of (RS)-(8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate sulfate (2:1) salt with sodium tetraphenylborate in deionized water at ambient temperature through anion exchange reaction. Colorless crystals of the title compound suitable for X-ray structural analysis were obtained by slow evaporation from acetonitrile. The title compound crystallizes in the triclinic sp. gr. P (1) over bar with a = 9.7989(5)angstrom , b = 9.8203(5)angstrom , c = 18.6099(9)angstrom , alpha = 81.356(2)degrees, beta = 80.616(2)degrees, gamma = 67.704(2)degrees, V = 1627.05(14)angstrom(3), Z = 2.

引用

页码：1083 / 1088

页数：6

共 16 条

[1] SPECTROPHOTOMETRIC DETERMINATION OF ATROPINE [J].