Heterotypic cell-in-cell structures between cancer and NK cells are associated with enhanced anticancer drug resistance

被引：10

作者：

Choe, Yun-Jeong ^{[1
]}

Min, Jin Young ^{[1
,2
]}

Lee, Hyunseong ^{[1
]}

Lee, Sang-Yeop ^{[1
]}

Kwon, Joseph ^{[3
]}

Kim, Hye-Jin ^{[4
]}

Lee, Jangho ^{[5
]}

Kim, Hyun Min ^{[1
]}

Park, Hye Sun ^{[1
]}

Cho, Mi Young ^{[1
]}

Hyun, Ju-Yong ^{[1
]}

Kim, Hye Min ^{[1
,6
]}

Chung, Yong-Ho ^{[1
,8
]}

Ha, Sang Keun ^{[5
,6
]}

Jeong, Hye Gwang ^{[2
]}

Choi, Inpyo ^{[6
,7
]}

Kim, Tae-Don ^{[6
,7
]}

Hong, Kwan Soo ^{[1
,8
]}

Han, Eun Hee ^{[1
,6
]}

机构：

[1] Korea Basic Sci Inst, Res Ctr Bioconvergence Anal, Cheongju 28119, South Korea

[2] Chungnam Natl Univ, Coll Pharm, Dept Toxicol, Daejeon 34134, South Korea

[3] Korea Basic Sci Inst, Res Ctr Mat Anal, Daejeon 34133, South Korea

[4] Tomocube Inc, Daejeon 34051, South Korea

[5] Korea Food Res Inst, Res Div Food Funct, Seongnam Si 55365, Jeonrabug Do, South Korea

[6] Korea Univ Sci & Technol UST, Daejeon 34113, South Korea

[7] Korea Res Inst Biosci & Biotechnol, Immunotherapy Res Ctr, Daejeon 34141, South Korea

[8] Chungnam Natl Univ, Grad Sch Analyt Sci & Technol, Daejeon 34134, South Korea

来源：

ISCIENCE | 2022年 / 25卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

Biophysics; Cancer; Cell biology;

D O I：

10.1016/j.isci.2022.105017

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The heterotypic CIC structures formed of cancer and immune cells have been observed in tumor tissues. We aimed to assess the feasibility of using heterotypic CICs as a functional biomarker to predict NK susceptibility and drug resistance. The heterotypic CIC-forming cancer cells showed a lower response to NK cyto-toxicity and higher proliferative ability than non-CIC cancer cells. After treatment with anticancer drugs, cancer cells that formed heterotypic CICs showed a higher resistance to anticancer drugs than non-CIC cancer cells. We also observed the formation of more CIC structures in cancer cells treated with anticancer drugs than in the non-treated group. Our results confirm the association between het-erotypic CIC structures and anticancer drug resistance in CICs formed from NK and cancer cells. These results suggest a mechanism underlying immune evasion in heterotypic CIC cancer cells and provide insights into the anticancer drug resis-tance of cancer cells.

引用

页数：21

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