The tumor suppressor role of Src homology phosphotyrosine phosphatase 2 in hepatocellular carcinoma
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作者:
Jiang, Chengying
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Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
Nankai Univ, Coll Med, Tianjin 300071, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
Jiang, Chengying
[1
,2
]
Hu, Fangke
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机构:
Nankai Univ, Coll Med, Tianjin 300071, Peoples R China
Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
Hu, Fangke
[2
,3
]
Tai, Yanhong
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机构:
Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
Tai, Yanhong
[1
]
Du, Jingli
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Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
Du, Jingli
[1
]
Mao, Beibei
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Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
Mao, Beibei
[4
]
Yuan, Zengqiang
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Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
Yuan, Zengqiang
[4
]
Wang, Yan
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Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
Wang, Yan
[3
]
Wei, Lixin
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Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
Wei, Lixin
[1
]
机构:
[1] Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
[2] Nankai Univ, Coll Med, Tianjin 300071, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Beijing 100853, Peoples R China
[4] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China
The human gene PTPN11, which encodes the non-receptor protein tyrosine phosphatase of Src homology phosphotyrosine phosphatase 2 (Shp2), has been previously well interpreted as a proto-oncogene in a variety of malignancies. However, the tumor suppressor role of Shp2 has also been reported. The present study was conducted to investigate the role of Shp2 expression and its associated clinical manifestations in hepatocellular carcinoma (HCC). A tissue microarray of 333 pairs of HCC and self-matched adjacent non-tumor tissues was constructed, and the expression of Shp2 was determined by immunohistochemistry. The results were also conformed by Western blotting and quantitative PCR of 31 self-paired fresh HCC specimens. The associations of Shp2 expression with 25 clinicopathologic features were analyzed. Overall survival analysis and multivariate analysis were performed. Significantly decreased Shp2 expression in tumor tissues (T) compared with adjacent non-tumor tissues (NT) could be detected, and the positive rate was 66.1 and 96.7%, respectively. We combined the T and NT Shp2 immunoreactivity by a variable of the decrease in Shp2 expression (Delta Shp2) and divided cases into 2 groups: T < NT and T a parts per thousand yen NT. Survival analysis showed both low Shp2 expression and T < NT group were significantly associated with short overall survival. Multivariate analysis showed Delta Shp2 was an independent prognostic marker (P = 0.033; HR: 0.527; 95% CI: 0.293-0.950). Shp2 is a tumor suppressor, and the decrease in Shp2 expression was a new prognostic marker in HCC. The oncogenic role of Shp2 was tissue specific, and the therapeutic target of human gene PTPN11 should be reconsidered.
机构:
Chinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Zhao, Hong
Wang, Jian
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Chinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Wang, Jian
Han, Yongqing
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机构:
Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China
Peking Union Med Coll, Beijing 100005, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Han, Yongqing
Huang, Zhen
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机构:
Chinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Huang, Zhen
Ying, Jianming
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机构:
Peking Union Med Coll, Beijing 100021, Peoples R China
Chinese Acad Med Sci, Canc Hosp, Dept Pathol, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Ying, Jianming
Bi, Xinyu
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Chinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Bi, Xinyu
Zhao, Jianjun
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Chinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Zhao, Jianjun
Fang, Yi
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Chinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Fang, Yi
Zhou, Haitao
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Chinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Zhou, Haitao
Zhou, Jianguo
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Chinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Zhou, Jianguo
Li, Zhiyu
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Chinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Li, Zhiyu
Zhang, Yefan
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Chinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Zhang, Yefan
Yang, Xue
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Chinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Yang, Xue
Yan, Tao
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Chinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Yan, Tao
Wang, Linfang
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Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China
Peking Union Med Coll, Beijing 100005, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Wang, Linfang
Torbenson, Michael S.
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Johns Hopkins Univ Sch Med, Dept Pathol, Baltimore, MD 21231 USAChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Torbenson, Michael S.
Cai, Jianqiang
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Chinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Canc Hosp, Dept Abdominal Surg Oncol, Beijing 100021, Peoples R China
机构:
Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Chiba Univ Hosp, Dept Diabet Metab & Endocrinol, Chiba, JapanChiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Suzuki, Sawako
Venkatesh, Divya
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Columbia Univ, Dept Biol Sci, New York, NY USAChiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Venkatesh, Divya
Kanda, Hiroaki
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机构:Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Kanda, Hiroaki
Nakayama, Akitoshi
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Chiba Univ, Grad Sch Med, Dept Mol Diag, Chiba, JapanChiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Nakayama, Akitoshi
Hosokawa, Hiroyuki
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Saitama Canc Ctr, Dept Pathol, Saitama, Japan
Tokai Univ Sch Med, Dept Immunol, Kanagawa, JapanChiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Hosokawa, Hiroyuki
Lee, Eunyoung
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Chiba Univ, Grad Sch Med, Dept Med Physiol, Chiba, JapanChiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Lee, Eunyoung
Miki, Takashi
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Chiba Univ, Grad Sch Med, Dept Med Physiol, Chiba, JapanChiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Miki, Takashi
Stockwell, Brent R.
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Columbia Univ, Dept Biol Sci, New York, NY USA
Columbia Univ, Dept Chem, New York, NY USAChiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Stockwell, Brent R.
Yokote, Koutaro
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Chiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Chiba Univ Hosp, Dept Diabet Metab & Endocrinol, Chiba, JapanChiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Yokote, Koutaro
Tanaka, Tomoaki
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Chiba Univ, Grad Sch Med, Dept Mol Diag, Chiba, Japan
Chiba Univ, Grad Sch Med, Dept Mol Diag, 1 8 1 Inohana Chuo ku, Chiba 2608670, JapanChiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
Tanaka, Tomoaki
Prives, Carol
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Columbia Univ, Dept Biol Sci, New York, NY USA
Columbia Univ, Dept Biol Sci, 816 Fairchild Bldg, New York, NY 10027 USAChiba Univ, Grad Sch Med, Dept Endocrinol Hematol & Gerontol, Chiba, Japan
机构:
455th Hosp Chinese PLA, Dept Otolaryngol Head & Neck Surg, Shanghai, Peoples R China455th Hosp Chinese PLA, Dept Otolaryngol Head & Neck Surg, Shanghai, Peoples R China
Dong, L. B.
Li, G. Q.
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455th Hosp Chinese PLA, Dept Pathol, Shanghai, Peoples R China455th Hosp Chinese PLA, Dept Otolaryngol Head & Neck Surg, Shanghai, Peoples R China
Li, G. Q.
Tian, Z. H.
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455th Hosp Chinese PLA, Dept Pathol, Shanghai, Peoples R China455th Hosp Chinese PLA, Dept Otolaryngol Head & Neck Surg, Shanghai, Peoples R China
Tian, Z. H.
Wang, Z. M.
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455th Hosp Chinese PLA, Dept Pathol, Shanghai, Peoples R China455th Hosp Chinese PLA, Dept Otolaryngol Head & Neck Surg, Shanghai, Peoples R China
Wang, Z. M.
Xu, K.
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455th Hosp Chinese PLA, Dept Pathol, Shanghai, Peoples R China455th Hosp Chinese PLA, Dept Otolaryngol Head & Neck Surg, Shanghai, Peoples R China
机构:
Hangzhou Normal Univ, Inst Life Sci, Zhejiang Key Lab Organ Dev & Regenerat, Hangzhou 310036, Zhejiang, Peoples R ChinaHainan Med Univ, Dept Biochem & Mol Biol, Haikou 571199, Hainan, Peoples R China
Zhang, Bin
Lu, Wen
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Hainan Med Univ, Dept Biochem & Mol Biol, Haikou 571199, Hainan, Peoples R ChinaHainan Med Univ, Dept Biochem & Mol Biol, Haikou 571199, Hainan, Peoples R China