Emerging insights into HAUSP (USP7) in physiology, cancer and other diseases

被引:130
作者
Bhattacharya, Seemana [1 ,2 ]
Chakraborty, Dipankar [1 ,2 ]
Basu, Malini [3 ]
Ghosh, Mrinal K. [1 ,2 ]
机构
[1] CSIR IICB, Div Canc Biol & Inflammatory Disorder, Signal Transduct Canc & Stem Cells Lab, 4 Raja SC Mullick Rd, Kolkata 700032, India
[2] CN-06,Sect 5, Kolkata 700091, India
[3] Barrackpore Rastraguru Surendranath Coll, Dept Microbiol, 6 Riverside Rd & 85 Middle Rd, Kolkata 700120, India
关键词
UBIQUITIN-SPECIFIC PROTEASE; SMALL-MOLECULE INHIBITOR; DEUBIQUITINATING ENZYME; CELL-PROLIFERATION; RECRUITS USP7; ACTIVATES P53; UP-REGULATION; PEPTIDASE; STABILITY; USP7/HAUSP;
D O I
10.1038/s41392-018-0012-y
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Herpesvirus-associated ubiquitin-specific protease (HAUSP) is a USP family deubiquitinase. HAUSP is a protein of immense biological importance as it is involved in several cellular processes, including host-virus interactions, oncogenesis and tumor suppression, DNA damage and repair processes, DNA dynamics and epigenetic modulations, regulation of gene expression and protein function, spatio-temporal distribution, and immune functions. Since its discovery in the late 1990s as a protein interacting with a herpes virus regulatory protein, extensive studies have assessed its complex roles in p53-MDM2-related networks, identified numerous additional interacting partners, and elucidated the different roles of HAUSP in the context of cancer, development, and metabolic and neurological pathologies. Recent analyses have provided new insights into its biochemical and functional dynamics. In this review, we provide a comprehensive account of our current knowledge about emerging insights into HAUSP in physiology and diseases, which shed light on fundamental biological questions and promise to provide a potential target for therapeutic intervention.
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页数:12
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