Palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of potassium 2-pyridyl trifluoroborate with aryl (heteroaryl) halides

被引:33
|
作者
Ren, Wei [1 ,2 ]
Li, Jingya [2 ]
Zou, Dapeng [1 ,2 ]
Wu, Yangjie [1 ]
Wu, Yusheng [2 ,3 ]
机构
[1] Zhengzhou Univ, Dept Chem, Key Lab Chem Biol & Organ Chem Henan Prov, Zhengzhou 450052, Henan, Peoples R China
[2] Tetranov Biopharm LLC, Zhengzhou 450052, Henan, Peoples R China
[3] Tetranov Int Inc, New Brunswick, NJ 08901 USA
基金
中国国家自然科学基金;
关键词
Palladium-catalyzed; Suzuki-Miyaura cross-coupling reaction; Potassium 2-pyridyl trifluoroborate; Aryl (heteroaryl) halides; ACIDS; COMPLEXES; ESTERS;
D O I
10.1016/j.tet.2011.12.036
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of potassium pyridine-2-trifluoroborates and various aryl (heteroaryl) halides can generate the corresponding desired coupling products with moderate to good yields. It can be carried out under the conditions with ethanol as solvent, Pd(OAc)(2) and SPhos as catalyst system and Na2CO3 as a base. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1351 / 1358
页数:8
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