Anticipatory coping of pain expressed in the human anterior cingulate cortex: a positron emission tomography study

被引：196

作者：

Hsieh, JC ^{[1
]}

Stone-Elander, S

Ingvar, M

机构：

[1] Karolinska Hosp & Inst, Dept Clin Neurosci, S-17176 Stockholm, Sweden

[2] Vet Gen Hosp, Dept Med Educ Res, Integrated Brain Res Unit, Taipei 11217, Taiwan

[3] Vet Gen Hosp, Dept Anesthesiol, Taipei 11217, Taiwan

[4] Natl Yang Ming Univ, Inst Neurosci, Taipei 11217, Taiwan

[5] Natl Yang Ming Univ, Sch Life Sci, Dept Med, Taipei 11217, Taiwan

[6] Natl Yang Ming Univ, Sch Med, Taipei 11217, Taiwan

[7] Natl Yang Ming Univ, Sch Med, Dept Med, Taipei 11217, Taiwan

[8] Karolinska Hosp, Karolinska Pharm, S-17176 Stockholm, Sweden

来源：

NEUROSCIENCE LETTERS | 1999年 / 262卷 / 01期

关键词：

positron emission tomography; regional cerebral blood flow; brain activation; anticipation; coping; pain; attention; emotion; human brain;

D O I：

10.1016/S0304-3940(99)00060-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We used positron emission tomography (PET) to monitor the regional cerebral blood flow (rCBF) as an index of brain activity in regions proposed to participate in affective-motivational and cognitive-evaluative dimensions of pain during anticipation of a noxious stimulation. Specifically we were interested in the anterior cingulate cortex (ACC), the ventromedial prefrontal cortex (VMPFC) and the periaqueductal grey (PAG). Anticipating an unpredictable and unlearned pain stimulus activated the right ACC, the VMPFC and the FAG while anticipating a learned pain-stimulus resulted in a decreased activity in the ACC and the VMPFC. These patterns are compatible with two facets of affect-laden cognitive coping: alertness and attention-distraction. The right-preponderant expression of the changes in the ACC supports the hypothesis of a preferential role of the non-dominant hemisphere in negative emotional processing. The data demonstrate an anticipatory coping mechanism and illustrate a neurophysiological process underlying the modulation of attention to pain. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：61 / 64

页数：4

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