Impact of Atorvastatin Combined with Ezetimibe for the Treatment of Carotid Atherosclerosis in Patients with Coronary Heart Disease

被引:22
作者
Luo, Ping [1 ]
Wang, Lixia [1 ]
Zhu, Haohui [2 ]
Du, Song [1 ]
Wang, Guanggong [1 ]
Ding, Shoukun [1 ]
机构
[1] Henan Prov Peoples Hosp, Dept Cardiol, 7 Weiwu Rd, Zhengzhou 450003, Peoples R China
[2] Henan Prov Peoples Hosp, Dept Ultrasound, Zhengzhou 450003, Peoples R China
关键词
Atorvastatin; Carotid atherosclerosis; Ezetimibe; INTIMA-MEDIA THICKNESS; CHOLESTEROL ABSORPTION; ENDOTHELIAL FUNCTION; JAPANESE PATIENTS; ARTERY-DISEASE; PLAQUE; HYPERCHOLESTEROLEMIA; PROGRESSION; REGRESSION; METAANALYSIS;
D O I
10.6515/ACS20151013H
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: This study aimed to investigate the impact of atorvastatin (Ato) combined with ezetimibe (Eze) for the treatment of carotid atherosclerosis in patients with coronary heart disease (CHD). Methods: One hundred and forty-eight CHD patients with carotid atherosclerosis were divided into the control (Ato alone) and combination (Ato and Eze) groups. The treatment course was 12 months; patient blood lipids, carotid intima-media thickness (CIMT), and carotid plaque area were measured before and after treatment. Results: Twelve months after treatment, there was a decrease in the CIMT, and the horizontal and vertical axes of the carotid plaque areas in both groups, compared to pretreatment values. The serum low-density lipoprotein cholesterol (LDL-C) levels were significantly decreased (p < 0.05). There were statistically significant differences (p < 0.05) in the LDL-C (2.12 +/- 0.58 mmol/L vs. 2.63 +/- 0.56 mmol/L) and CIMT (1.06 +/- 0.12 mm vs. 1.13 +/- 0.11 mm) levels between the combination and the control groups after treatment. Compared to the control group, the horizontal (0.18 +/- 0.06 cm(2)vs. 0.19 +/- 0.05 cm(2)) and vertical carotid arterial plaque areas (0.40 +/- 0.15 cm(2) vs. 0.41 +/- 0.17 cm(2)) of the combination group were reduced after treatment. However, the difference was not statistically significant (p > 0.05). Conclusions: The combination of Ato and Eze further reduces LDL-C levels and CIMT, and affect the progression of carotid atherosclerosis in CHD patients with hypercholesterolemia.
引用
收藏
页码:578 / 585
页数:8
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