Isolation, structural elucidation, and synthesis of RA-XVII, a novel bicyclic hexapeptide from Rubia cordifolia, and the effect of side chain at residue 1 upon the conformation and cytotoxic activity

被引：24

作者：

Hitotsuyanagi, Y ^{[1
]}

Ishikawa, H ^{[1
]}

Hasuda, T ^{[1
]}

Takeya, K ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 05期

关键词：

D O I：

10.1016/j.tetlet.2003.11.112

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel antitumor bicyclic hexapeptide RA-XVII was isolated from the roots of Rubia cordifolia. By spectral studies and synthetic approach, its structure was determined to be [D-2-aminobutyric acid-1]deoxybouvardin. Studies on the effect of side chain at residue 1 on cytotoxic activity and conformation showed that although it had little effect on the conformation of the molecule, it decreased the activity as it grew longer. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：935 / 938

页数：4

共 14 条

[1] RA-dimer A, a novel dimeric antitumor bicyclic hexapeptide from Rubia cordifolia L. [J].