Brain damage and cardiopulmonary bypass: is there really any association?

被引：9

作者：

Alston, R. P. ^{[1
]}

机构：

[1] Royal Infirm Edinburgh NHS Trust, Dept Anaesthesia Crit & Pain Med, Edinburgh EH16 4SA, Midlothian, Scotland

来源：

PERFUSION-UK | 2011年 / 26卷

关键词：

cardiopulmonary bypass; heart-lung machine; brain damage; stroke; cognition; neuropsychological tests; randomized control trial; meta-analysis; systematic review; CORONARY-ARTERY-BYPASS; OFF-PUMP SURGERY; ON-PUMP; RANDOMIZED-TRIALS; COGNITIVE OUTCOMES; METAANALYSIS; MORBIDITY; STROKE; REVASCULARIZATION; VARIABLES;

D O I：

10.1177/0267659111408756

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Brain damage, in the form of stroke and cognitive deficit associated with heart surgery, has long been attributed unquestioningly to cardiopulmonary bypass (CPB). The aim of this paper is to review the randomised control trials (RCT), systematic reviews and meta-analyses of studies, comparing patients who have undergone on-or off-pump coronary artery bypass grafting (CABG) surgeries that have used stroke or cognition as an outcome to determine whether CPB is associated with brain damage. Although not definitive, the evidence base to date strongly suggests that the incidence of stroke and the effect on cognition, if any, are no different whether CABG surgery is undertaken on-or off-pump. In addition and contrary to long-held beliefs, this review leads to the conclusion that CPB may well not be the cause of the brain damage associated with heart surgery.

引用

页码：20 / 26

页数：7

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