Systems Biology Analysis of Heterocellular Signaling

被引：24

作者：

Tape, Christopher J. ^{[1
,2
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机构：

[1] Inst Canc Res, 237 Fulham Rd, London SW3 6JB, England

[2] MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2016年 / 34卷 / 08期

基金：

英国惠康基金;

关键词：

SINGLE-CELL ANALYSIS; PROTEOMIC ANALYSIS; POSTTRANSLATIONAL MODIFICATIONS; MASS-SPECTROMETRY; CANCER; TRANSDUCTION; NETWORKS; TISSUES; TUMOR; PHOSPHORYLATION;

D O I：

10.1016/j.tibtech.2016.02.016

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Tissues comprise multiple heterotypic cell types (e.g., epithelial, mesenchymal, and immune cells). Communication between heterotypic cell types is essential for biological cohesion and is frequently dysregulated in disease. Despite the importance of heterocellular communication, most systems biology techniques do not report cell-specific signaling data from mixtures of cells. As a result, our existing perspective of cellular behavior under-represents the influence of heterocellular signaling. Recent technical advances now permit the resolution of systems-level cell-specific signaling data. This review discusses how new physical, spatial, and isotopic resolving methods are facilitating unique systems biology studies of heterocellular communication.

引用

页码：627 / 637

页数：11

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