Extended targeting potential and improved synthesis of Microcin C analogs as antibacterials

被引：26
|
作者：
Vondenhoff, Gaston H. M. [1 ]
Dubiley, Svetlana [3 ]
Severinov, Konstantin [2 ,3 ]
Lescrinier, Eveline [1 ]
Rozenski, Jef [1 ]
Van Aerschot, Arthur [1 ]
机构：
[1] Katholieke Univ Leuven, Med Chem Lab, Rega Inst Med Res, B-3000 Louvain, Belgium
[2] Rutgers State Univ, Waksman Inst, Piscataway, NJ 08854 USA
[3] Russian Acad Sci, Inst Gene Biol, Moscow, Russia
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2011年 / 19卷 / 18期
关键词：
Microcin C analogs; Antibiotics; Drug design; TRANSFER-RNA SYNTHETASE; MATURATION; ANTIBIOTICS; DESIGN; NEED;
D O I：
10.1016/j.bmc.2011.07.052
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Microcin C (McC) (1) is a potent antibacterial compound produced by some Escherichia coli strains. McC functions through a Trojan-Horse mechanism: it is actively taken up inside a sensitive cell through the function of the YejABEF-transporter and then processed by cellular aminopeptidases. Processed McC (2) is a non-hydrolysable aspartyl-adenylate analog that inhibits aspartyl-tRNA synthetase (AspRS). A new synthesis is described that allows for the production of a wide variety of McC analogs in acceptable amounts. Using this synthesis a number of diverse compounds was synthesized with altered target specificity. Further characteristics of the YejABEF transporters were determined using these compounds. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5462 / 5467
页数：6
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