Paths of convergence: Sirtuins in aging and neurodegeneration

被引:156
作者
Gan, Li [1 ,2 ]
Mucke, Lennart [1 ,2 ]
机构
[1] Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA
[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA
关键词
D O I
10.1016/j.neuron.2008.03.015
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Members of the sirtuin family of protein deacetylases support and promote longevity in diverse organisms and can extend life span when upregulated. Sirtuin pathways also modulate fundamental mechanisms in aging-related neurodegenerative diseases, including protein aggregation, stress responses, mitochondrial homeostasis, and inflammatory processes. In this minireview, we will discuss how progress in understanding the neurobiology of sirtuins is shedding light on the pathogenesis of these devastating conditions. We will also examine the potential and challenges of targeting sirtuin pathways therapeutically.
引用
收藏
页码:10 / 14
页数:5
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