Functionalization of luminescent cyclometalated iridium(III) polypyridine complexes with a fluorous moiety: photophysics, protein-binding, bioconjugation, and cellular uptake properties

被引:46
作者
Leung, Siu-Kit [1 ]
Liu, Hua-Wei [1 ]
Lo, Kenneth Kam-Wing [1 ]
机构
[1] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
关键词
MASS-SPECTROMETRY; EXPLOITATION; SALTS; ION;
D O I
10.1039/c1cc11423a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A new class of luminescent cyclometalated iridium(III) polypyridine fluorous complexes has been designed; the fluorous pendant not only plays an important role in the photophysical and biological properties of the complexes, but also allows the facile isolation of biomolecules labeled with these complexes with fluorous solid-phase extraction (FSPE).
引用
收藏
页码:10548 / 10550
页数:3
相关论文
共 27 条
[1]   Noncovalent attachment of nucleotides by fluorous fluorous interactions: Application to a simple purification principle for synthetic DNA fragments [J].
Beller, C ;
Bannwarth, W .
HELVETICA CHIMICA ACTA, 2005, 88 (01) :171-179
[2]   Enrichment and analysis of peptide subsets using fluorous affinity tags and mass spectrometry [J].
Brittain, SM ;
Ficarro, SB ;
Brock, A ;
Peters, EC .
NATURE BIOTECHNOLOGY, 2005, 23 (04) :463-468
[3]   Highly efficient blue-emitting iridium(III) carbene complexes and phosphorescent OLEDs [J].
Chang, Chiung-Fang ;
Cheng, Yi-Ming ;
Chi, Yun ;
Chiu, Yuan-Chieh ;
Lin, Chao-Chen ;
Lee, Gene-Hsiang ;
Chou, Pi-Tai ;
Chen, Chung-Chia ;
Chang, Chih-Hao ;
Wu, Chung-Chih .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (24) :4542-4545
[4]   Molecularly Tethered Amphiphiles as 3-D Supramolecular Assembly Platforms: Unlocking a Trapped Conformation [J].
Clark, Christopher G., Jr. ;
Floudas, George A. ;
Lee, Young Joo ;
Graf, Robert ;
Spiess, Hans W. ;
Muellen, Klaus .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (24) :8537-8547
[5]  
Curran D., 2004, HDB FLUOROUS CHEM
[6]   FACILE CATALYST SEPARATION WITHOUT WATER - FLUOROUS BIPHASE HYDROFORMYLATION OF OLEFINS [J].
HORVATH, IT ;
RABAI, J .
SCIENCE, 1994, 266 (5182) :72-75
[7]   Synthesis and quantitative evaluation of Glycero-D-manno-heptose binding to concanavalin a by fluorous-tag assistance [J].
Jaipuri, Firoz A. ;
Collet, Beatrice Y. M. ;
Pohl, Nicola L. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (09) :1707-1710
[8]   Unique properties of a perfluoroalkyl-modified 2,2′-bipyridyl ruthenium complex in a Nafion™ membrane:: attenuated leaching of a potential biofuel cell redox mediator [J].
Jelliss, Paul A. ;
Minteer, Shelley D. ;
Patel, Mitesh ;
Siemiarczuk, Aleksander ;
Watt, Michelle ;
Winter, Rudolph E. K. .
JOURNAL OF MATERIALS CHEMISTRY, 2008, 18 (18) :2104-2111
[9]   Zwitterionic Iridium Complexes: Synthesis, Luminescent Properties, and Their Application in Cell Imaging [J].
Jiang, Weili ;
Gao, Yuan ;
Sun, Yun ;
Ding, Fei ;
Xu, Yan ;
Bian, Zuqiang ;
Li, Fuyou ;
Bian, Jiang ;
Huang, Chunhui .
INORGANIC CHEMISTRY, 2010, 49 (07) :3252-3260
[10]   Design of Luminescent Biotinylation Reagents Derived from Cyclometalated Iridium(III) and Rhodium(III) Bis(pyridylbenzaldehyde) Complexes [J].
Leung, Siu-Kit ;
Kwok, Karen Ying ;
Zhang, Kenneth Yin ;
Lo, Kenneth Kam-Wing .
INORGANIC CHEMISTRY, 2010, 49 (11) :4984-4995