Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson's disease

被引：32

作者：

Tsui, Alex ^{[1
,2
,3
]}

Isacson, Ole ^{[1
]}

机构：

[1] Harvard Univ, McLean Hosp, Neuroregenerat Labs, Belmont, MA USA

[2] Univ Oxford, John Radcliffe Hosp, Sch Med, Oxford OX3 9DU, England

[3] Corpus Christi Coll, Oxford OX14JF, England

来源：

JOURNAL OF NEUROLOGY | 2011年 / 258卷 / 08期

基金：

欧洲研究理事会;

关键词：

Parkinson's; Movement disorders; Neurotransplantation; Foetal grafting; Dyskinesias; Normal striatum; MESSENGER-RNA LEVELS; SUBSTANTIA-NIGRA; RECEPTOR SUPERSENSITIVITY; PEDUNCULOPONTINE NUCLEUS; PRESYNAPTIC MECHANISMS; MOTOR COMPLICATIONS; INDUCED DYSKINESIA; PRIMATE MODEL; NEURONS; TRANSPLANTATION;

D O I：

10.1007/s00415-011-6061-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

While pharmaceutical options remain the overwhelmingly accepted treatment of choice for neurological and psychiatric diseases, significant accomplishments in regenerative neuroscience research have demonstrated the potential of cellular and synaptic functional repair in future therapies. Parkinson's disease stands out as an example in which repair by dopaminergic neurons appears a viable potential therapy. This article describes the basic neurobiological underpinnings of the rationale for cell therapy for Parkinson's disease and the challenges ahead for the use of regenerative medicine in the treatment for this disease.

引用

页码：1393 / 1405

页数：13

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