Correlation between cystatin C and serum creatinine as markers of renal function in patients with neoplasms of the locomotor system

被引：6
作者：
Zolezzi, C
Ferrari, S
Fasano, MC
Telentinis, L
Bacci, G
Pizzoferrato, A
机构：
[1] Ist Ortoped Rizzoli, Lab Med, I-40136 Bologna, Italy
[2] Ist Ortoped Rizzoli, Dept Chemotherapy, I-40136 Bologna, Italy
来源：
JOURNAL OF CHEMOTHERAPY | 2001年 / 13卷 / 03期
关键词：
cystatin C; creatinine; creatinine clearance; renal function;
D O I：
10.1179/joc.2001.13.3.316
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Creatinine levels and clearance are used to monitor renal function in clinical practice, Cystatin C is produced by most nucleated cells its a consistent manner, uninfluenced by inflammatory processes, sex, age, eating habits or nutritional status. Serum cystatin C concentrations are mainly dependent on glomerular activity and are an endogenous biochemical marker of glomerular filtration. The aim of this study was to test the efficiency of cystatin C assay as an alternative marker of renal function, Statistical analysis of our results showed that cystatin C levels were significantly correlated to creatinine and creatinine clearance levels. However, it is still premature to suppose that cystatin C can replace creatinine in routine tests, Establishing cystatin C levels can be useful in cases in which it is not possible to determine creatinine clearance.
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页码：316 / 323
页数：8
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