Neonatal reversible focal cerebral ischemia: a new model

被引：74
作者：
Derugin, N
Ferriero, DM
Vexler, ZS
机构：
[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA
来源：
NEUROSCIENCE RESEARCH | 1998年 / 32卷 / 04期
关键词：
stroke; neonate; middle cerebral artery occlusion; reversible cerebral ischemia; TTC;
D O I：
10.1016/S0168-0102(98)00096-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
While numerous animal models exist for studying neonatal brain injury after cerebral ischemia-hypoxia, an adequate model for assessing reversible focal ischemia in the neonatal rat has not been reported. This paper describes in detail a new surgical procedure for creating a non-hemorrhagic, reperfused focal ischemic lesion in the neonatal, 7-day-old rat pup. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：349 / 353
页数：5
相关论文
共 19 条
[1]   A NEW MODEL OF NEONATAL STROKE - REVERSIBLE MIDDLE CEREBRAL-ARTERY OCCLUSION IN THE RAT PUP [J].
ASHWAL, S ;
COLE, DJ ;
OSBORNE, S ;
OSBORNE, TN ;
PEARCE, WJ .
PEDIATRIC NEUROLOGY, 1995, 12 (03) :191-196
[2]   Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury [J].
Cheng, Y ;
Deshmukh, M ;
D'Costa, A ;
Demaro, JA ;
Gidday, JM ;
Shah, A ;
Sun, YL ;
Jacquin, MF ;
Johnson, EM ;
Holtzman, DM .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (09) :1992-1999
[3]   THE QUANTIFICATION OF CEREBRAL INFARCTION FOLLOWING FOCAL ISCHEMIA IN THE RAT - INFLUENCE OF STRAIN, ARTERIAL-PRESSURE, BLOOD-GLUCOSE CONCENTRATION, AND AGE [J].
DUVERGER, D ;
MACKENZIE, ET .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1988, 8 (04) :449-461
[4]   Bcl-2, Bax and Bcl-x expression following hypoxia-ischemia in the infant rat brain [J].
Ferrer, I ;
Pozas, E ;
Lopez, E ;
Ballabriga, J .
ACTA NEUROPATHOLOGICA, 1997, 94 (06) :583-589
[5]  
KOELFEN W, 1995, DEV MED CHILD NEUROL, V37, P204
[6]  
Koizumi J., 1986, JPN J STROKE, V8, P1, DOI [10.3995/jstroke.8.1, DOI 10.3995/JSTROKE.8.1]
[7]   ECHO-PLANAR PERFUSION-SENSITIVE MR-IMAGING OF ACUTE CEREBRAL-ISCHEMIA [J].
KUCHARCZYK, J ;
VEXLER, ZS ;
ROBERTS, TP ;
ASGARI, HS ;
MINTOROVITCH, J ;
DERUGIN, N ;
WATSON, AD ;
MOSELEY, ME .
RADIOLOGY, 1993, 188 (03) :711-717
[8]  
LEVINE S, 1960, AM J PATHOL, V36, P1
[9]   REVERSIBLE MIDDLE CEREBRAL-ARTERY OCCLUSION WITHOUT CRANIECTOMY IN RATS [J].
LONGA, EZ ;
WEINSTEIN, PR ;
CARLSON, S ;
CUMMINS, R .
STROKE, 1989, 20 (01) :84-91
[10]   PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ROLES OF EXCITATORY AMINO-ACIDS DURING CENTRAL-NERVOUS-SYSTEM DEVELOPMENT [J].
MCDONALD, JW ;
JOHNSTON, MV .
BRAIN RESEARCH REVIEWS, 1990, 15 (01) :41-70
12