Marine and Soil Derived Natural Products: A New Source of Novel Cardiovascular Protective Agents Targeting the Endothelin System

被引：4
作者：
Planes, Nadir [1 ,2 ]
Caballero-George, Catherina [1 ]
机构：
[1] Inst Sci Res & High Technol Serv, Panama City, Panama
[2] Acharya Nagarjuna Univ, Dept Biotechnol, Guntur, India
来源：
PLANTA MEDICA | 2015年 / 81卷 / 08期
关键词：
endothelin; hypertension; cardiovascular; marine natural products; microorganisms; ecology; RECEPTOR ANTAGONISTS; STACHYBOTRYS SP; STRUCTURE ELUCIDATION; THERAPEUTIC TARGET; FERMENTATION; INHIBITOR; TAXONOMY; AZAPHILONES; SPONGE; HYPERTENSION;
D O I：
10.1055/s-0034-1396205
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Inhibition of the endothelin system is a recognized therapeutic approach for treating complex cardiovascular diseases. The search for natural inhibitors of the endothelin system has focused mainly on land, with recent, emerging data suggesting the underestimated potential of marine microorganisms for producing leads with cardio-protective potential. The present work reviews natural products identified as inhibitors of the endothelin system, their origin, their mechanism of action, and their ecological significance.
引用
收藏
页码：630 / 636
页数：7
相关论文
共 60 条
  • [1] Role of endothelin in cardiovascular disease
    Agapitov, AV
    Haynes, WG
    [J]. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2002, 3 (01) : 1 - 15
  • [2] ISOLATION AND AMINO ACID SEQUENCE OF ELEDOISIN, ACTIVE ENDECAPEPTIDE OF POSTERIOR SALIVARY GLANDS OF ELEDONE
    ANASTASI, A
    ERSPAMER, V
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1963, 101 (01) : 56 - &
  • [3] [Anonymous], CURR TRENDS BIOTECHN
  • [4] Blunt JW, 2014, NAT PROD REP, V31, P160, DOI [10.1039/c7np00052a, 10.1039/c3np70117d]
  • [5] Fluorescence Correlation Spectroscopy in Drug Discovery: Study of Alexa532-Endothelin 1 Binding to the Endothelin ETA Receptor to Describe the Pharmacological Profile of Natural Products
    Caballero-George, Catherina
    Sorkalla, Thomas
    Jakobs, Daniel
    Bolanos, Jessica
    Raja, Huzefa
    Shearer, Carol
    Bermingham, Eldredge
    Haeberlein, Hanns
    [J]. SCIENTIFIC WORLD JOURNAL, 2012,
  • [6] CASEY ML, 1991, J BIOL CHEM, V266, P5762
  • [7] The Chemistry and Biology of Theta Defensins
    Conibear, Anne C.
    Craik, David J.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (40) : 10612 - 10623
  • [8] PHARMACOLOGICALLY ACTIVE SUBSTANCES FROM SOUTHERN PACIFIC MARINE-INVERTEBRATES
    ENDO, M
    NAKAGAWA, M
    HAMAMOTO, Y
    ISHIHAMA, M
    [J]. PURE AND APPLIED CHEMISTRY, 1986, 58 (03) : 387 - 394
  • [9] Comazaphilones A-F, Azaphilone Derivatives from the Marine Sediment-Derived Fungus Penicillium commune QSD-17
    Gao, Shu-Shan
    Li, Xiao-Ming
    Zhang, Yi
    Li, Chun-Shun
    Cui, Chuan-Ming
    Wang, Bin-Gui
    [J]. JOURNAL OF NATURAL PRODUCTS, 2011, 74 (02): : 256 - 261
  • [10] The function of terpene natural products in the natural world
    Gershenzon, Jonathan
    Dudareva, Natalia
    [J]. NATURE CHEMICAL BIOLOGY, 2007, 3 (07) : 408 - 414
123456