Kinamycin-mediated DNA cleavage under biomimetic conditions

被引：27

作者：

Ballard, T. Eric ^{[1
]}

Melander, Christian ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 19期

关键词：

D O I：

10.1016/j.tetlet.2008.03.019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The kinamycins are biologically active secondary metabolites characterized by an uncommon diazobenzo[b]fluorene skeleton. Kinamycin D has been shown to potently cleave DNA under mild biomimetic conditions. Use of the endogenously abundant reductant glutathione at 570 mu M, kinamycin D effectively cleaved DNA in a concentration, temperature, and time-dependent fashion. Dithiothreitol also proved effective at low concentration while other reductants failed to induce DNA cleavage. Mechanistic consequences of the DNA cleavage results are described. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3157 / 3161

页数：5

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