Copper-catalyzed tandem reaction between imines and alcohols leading to indoles

被引：45
作者：
Kamijo, S
Sasaki, Y
Yamamoto, Y [1 ]
机构：
[1] Tohoku Univ, Res Ctr Sustainable Mat Engn, Inst Multidisciplinary Res Adv Mat, Sendai, Miyagi 9808578, Japan
[2] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 01期
基金：
日本学术振兴会;
关键词：
indole; copper catalyst; imine; alkyne; alcohol;
D O I：
10.1016/j.tetlet.2003.10.141
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed tandem reaction between 2-alkynyl-N-arylideneanilines and alcohols is found to produce N-(alkoxybenzyl)indoles in good to high yields. A wide variety of substituted N-(alkoxybenzyl)indole derivatives call be synthesized by utilizing this protocol, since the derived indoles are essentially formed by the four-component assemblies of aldehydes, 2-iodoanilines, terminal alkynes, and alcohols. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：35 / 38
页数：4
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