Deep brain stimulation for epilepsy in clinical practice and in animal models

被引：49
|
作者：
Zhong, Xiao-Ling [1 ]
Yu, Jin-Tai [1 ,2 ]
Zhang, Qun [1 ]
Wang, Nai-Dong [3 ]
Tan, Lan [1 ,2 ]
机构：
[1] Qingdao Univ, Dept Neurol, Qingdao Municipal Hosp, Sch Med, Qingdao 266071, Peoples R China
[2] Ocean Univ China, Coll Med & Pharmaceut, Qingdao 266003, Peoples R China
[3] Qingdao Univ, Dept Neurol, Affiliated Hosp, Coll Med, Qingdao 266011, Peoples R China
来源：
BRAIN RESEARCH BULLETIN | 2011年 / 85卷 / 3-4期
基金：
中国国家自然科学基金;
关键词：
Deep brain stimulation; Epilepsy; Anterior nucleus of thalamus; Treatment; TEMPORAL-LOBE EPILEPSY; TERM-FOLLOW-UP; CHRONIC CEREBELLAR STIMULATION; HIGH-FREQUENCY STIMULATION; HIPPOCAMPAL ELECTRICAL-STIMULATION; CENTROMEDIAN THALAMIC NUCLEUS; PILOCARPINE-INDUCED SEIZURES; SUBTHALAMIC NUCLEUS; ANTERIOR NUCLEUS; LONG-TERM;
D O I：
10.1016/j.brainresbull.2011.03.020
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Given the tremendous success of deep brain stimulation (DBS) for the treatment of movement and neuropsychiatric disorders, clinicians have begun to open up to the possible use of electrical stimulation for the treatment of patients with uncontrolled seizures. DBS of various neural targets has been investigated in clinical studies and animal studies, including the anterior nucleus of thalamus (ANT), cerebellum, hippocampus, subthalamic nucleus (STN), centromedian nucleus of the thalamus (CMT), caudate nucleus (CN). Recently, a large and multicenter trial (SANTE: Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy) was conducted and subsequently with encouraging results, making ANT the most well-established target for DBS in the treatment of epilepsy to date. Here, we endeavor to review mainly the animal studies and clinical studies of ANT DBS to further explore the more reliable target. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：81 / 88
页数：8
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