Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018

被引：14

作者：

Banales, Jesus M. ^{[1
]}

Feldstein, Ariel E. ^{[2
]}

Saenger, Hanna ^{[3
]}

Lukacs-Kornek, Veronika ^{[4
]}

Szabo, Gyongyi ^{[5
]}

Kornek, Miroslaw ^{[6
,7
]}

机构：

[1] Univ Basque Country, Donostia Univ Hosp, Dept Liver & Gastrointestinal Dis, Biodonostia Hlth Res Inst,CIBERehd,Ikerbasque, San Sebastian, Spain

[2] Univ Calif San Diego, Div Pediat Gastroenterol Hepatol & Nutr, San Diego, CA 92103 USA

[3] Saarland Univ, Med Ctr, Dept Med 2, Homburg, Germany

[4] Rhein Friedrich Wilhelms Univ, Univ Hosp, Inst Expt Immunol, Bonn, Germany

[5] Univ Massachusetts, Med Ctr, Dept Med, Worcester, MA USA

[6] Univ Hosp Bonn, Dept Oncol Hematol & Rheumatol, Bonn, Germany

[7] German Armed Forces Cent Hosp, Dept Gen Visceral & Thorac Surg, Koblenz, Germany

来源：

HEPATOLOGY COMMUNICATIONS | 2019年 / 3卷 / 02期

基金：

美国国家卫生研究院;

关键词：

HEPATIC STELLATE CELLS; NONALCOHOLIC STEATOHEPATITIS; MEMBRANE-VESICLES; MICRORNA; MICROPARTICLES; EXOSOMES; CHOLANGIOCARCINOMA; BIOMARKERS; RELEASE; PROTEIN;

D O I：

10.1002/hep4.1300

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Extracellular vesicles (EVs) are small and heterogeneous membrane-bound structures released by cells and found in all biological fluids. They are effective intercellular communicators, acting on a number of close and/or distant target cells. EV cargo may reflect the cell of origin as well as the specific stress that induces their formation and release. They transport a variety of bioactive molecules, including messenger RNA, noncoding RNAs, proteins, lipids, and metabolites, that can be transferred among cells, regulating various cell responses. Alteration in the concentration and composition of EVs in biological fluids is a typical hallmark of pathologies in different liver diseases. Circulating EVs can serve as biomarkers or as messengers following uptake by other cells. This review is a meeting report from the International Liver Congress 2018 (European Association for the Study of the Liver) celebrated in Paris (Symposium: Extracellular vesicles and signal transmission) that discusses the role of EVs in several liver diseases, highlighting their potential value as disease biomarkers and therapeutic opportunities.

引用

页码：305 / 315

页数：11

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