Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells

被引：37

作者：

Chang, Jui-Ting ^{[1
]}

Liang, Yao-Jen ^{[2
,3
]}

Hsu, Chia-Yu ^{[2
]}

Chen, Chao-Yi ^{[3
]}

Chen, Po-Jung ^{[3
]}

Yang, Yi-Feng ^{[3
]}

Chen, Yen-Lin ^{[4
,6
]}

Pei, Dee ^{[5
,6
]}

Chang, Jin-Biou ^{[7
]}

Leu, Jyh-Gang ^{[1
,6
]}

机构：

[1] Shin Kong Wu Ho Su Mem Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan

[2] Fu Jen Catholic Univ, Dept & Inst Life Sci, New Taipei, Taiwan

[3] Fu Jen Catholic Univ, Grad Inst Appl Sci & Engn, New Taipei, Taiwan

[4] Fu Jen Catholic Univ, Cardinal Tien Hosp, Med Sch, Dept Pathol, New Taipei, Taiwan

[5] Fu Jen Catholic Univ, Div Endocrinol & Metab, Dept Internal Med, Cardinal Tien Hosp,Med Sch, New Taipei, Taiwan

[6] Fu Jen Catholic Univ, Sch Med, 510,Zhongzheng Rd, New Taipei 24205, Taiwan

[7] Tri Serv Gen Hosp, Dept Pathol, Natl Def Med Ctr, Div Clin Pathol, Taipei, Taiwan

来源：

BMC PHARMACOLOGY & TOXICOLOGY | 2017年 / 18卷

关键词：

Diabetic nephropathy; Glucagon-like peptide; Mesangial cell; PPAR delta; Rage; PROTEIN-KINASE-A; DIABETIC-NEPHROPATHY; OXIDATIVE STRESS; GLP-1; RECEPTOR; INDUCED APOPTOSIS; HEME OXYGENASE-1; RENAL-FAILURE; EXPRESSION; ACTIVATION; EXENDIN-4;

D O I：

10.1186/s40360-017-0172-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Hyperglycemia-induced advanced glycation end products (AGEs) and receptor for AGEs (RAGE) production play major roles in progression of diabetic nephropathy. Anti-RAGE effect of peroxisome proliferator-activated receptor-delta (PPARd) agonists was shown in previous studies. PPARd agonists also stimulate glucagon-like peptide-1 (GLP-1) secretion from human intestinal cells. Methods: In this study, the individual and synergic anti-inflammatory effects of GLP-1 receptor (exendin-4) and PPAR delta (L-165,041) agonists in AGE-treated rat mesangial cells (RMC) were investigated. Results: The results showed both exendin-4 and L-165,041 significantly attenuated AGE-induced IL-6 and TNF-alpha production, RAGE expression, and cell death in RMC. Similar anti-inflammatory potency was seen between 0.3 nM exendin-4 and 1 mu M L-165,041. Synergic effect of exendin-4 and L-165,041 was shown in inhibiting cytokines production, but not in inhibiting RAGE expression or cell death. Conclusions: These results suggest that both GLP-1 receptor and PPARd agonists have anti-inflammatory effect on AGE-treated rat mesangial cells.

引用

页数：9

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