LassoProt: server to analyze biopolymers with lassos

被引：50

作者：

Dabrowski-Tumanski, Pawel ^{[1
,2
]}

Niemyska, Wanda ^{[2
,3
]}

Pasznik, Pawel ^{[2
]}

Sulkowska, Joanna I. ^{[1
,2
]}

机构：

[1] Univ Warsaw, Fac Chem, Pasteura 1, Warsaw, Poland

[2] Univ Warsaw, Ctr New Technol, Banacha 2c, Warsaw, Poland

[3] Univ Silesia, Inst Math, Bankowa 14, Katowice, Poland

来源：

NUCLEIC ACIDS RESEARCH | 2016年 / 44卷 / W1期

关键词：

PROTEIN; CONSERVATION; PKNOT; DNA;

D O I：

10.1093/nar/gkw308

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The LassoProt server, http://lassoprot.cent.uw.edu.pl/, enables analysis of biopolymers with entangled configurations called lassos. The server offers various ways of visualizing lasso configurations, as well as their time trajectories, with all the results and plots downloadable. Broad spectrum of applications makes LassoProt a useful tool for biologists, biophysicists, chemists, polymer physicists and mathematicians. The server and our methods have been validated on the whole PDB, and the results constitute the database of proteins with complex lassos, supported with basic biological data. This database can serve as a source of information about protein geometry and entanglement-function correlations, as a reference set in protein modeling, and for many other purposes.

引用

页码：W383 / W389

页数：7

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