Evolution of the mitochondrial fusion-fission cycle and its role in aging

被引:103
作者
Kowald, Axel [1 ,2 ]
Kirkwood, Tom B. L. [2 ]
机构
[1] Humboldt Univ, Inst Biol, D-10115 Berlin, Germany
[2] Newcastle Univ, Inst Ageing & Hlth, Ctr Integrated Syst Biol Ageing & Nutr, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
基金
英国生物技术与生命科学研究理事会;
关键词
mechanistic aging theory; mathematical model; FREE-RADICAL THEORY; DNA MUTATIONS; DEGENERATIVE DISEASES; RESPIRATORY-CHAIN; GENE-EXPRESSION; IN-VIVO; CELLS; DYNAMICS; GENOME; CHLOROPLASTS;
D O I
10.1073/pnas.1101604108
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Mitochondria are organelles of eukaryotic cells that contain their own genetic material and evolved from prokaryotic ancestors some 2 billion years ago. They are the main source of the cell's energy supply and are involved in such important processes as apoptosis, mitochondrial diseases, and aging. During recent years it also became apparent that mitochondria display a complex dynamical behavior of fission and fusion, the function of which is as yet unknown. In this paper we develop a concise theory that explains why fusion and fission have evolved, how these processes are related to the accumulation of mitochondrial mutants during aging, why the mitochondrial DNA has to be located close to the respiration complexes where most radicals are generated, and what selection pressures shaped the slightly different structure of animal and plant mitochondria. We believe that this "organelle control" theory will help in understanding key processes involved in the evolution of the mitochondrial genome and the aging process.
引用
收藏
页码:10237 / 10242
页数:6
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