Fibroblast growth factor 23 serum level in type 2 diabetic italian subjects with peripheral arterial disease and critical limb ischemia

被引：2
|
作者：
Biscetti, F. [1 ,2 ]
Straface, G. [3 ]
Pitocco, D. [4 ]
Angelini, F. [2 ]
Tinelli, G. [5 ]
Landolfi, R. [6 ]
Flex, A. [2 ,6 ]
机构：
[1] Univ Cattolica Sacro Cuore, Sch Med, Fdn A Gemelli Univ Hosp, Inst Rheumatol & Affine Sci, Rome, Italy
[2] Univ Cattolica Sacro Cuore, Sch Med, Lab Vasc Biol & Genet, Rome, Italy
[3] St M Goretti Hosp, Dept Med, Latina, Italy
[4] Univ Cattolica Sacro Cuore, Sch Med, Fdn A Gemelli Univ Hosp, Diabet Care Unit,Dept Internal Med, Rome, Italy
[5] Univ Cattolica Sacro Cuore, Sch Med, Fdn A Gemelli Univ Hosp, Dept Vasc Surg, Rome, Italy
[6] Univ Cattolica Sacro Cuore, Sch Med, Fdn A Gemelli Univ Hosp, Dept Internal Med, Rome, Italy
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2016年 / 20卷 / 19期
关键词：
Type; 2; diabetes; Fibroblast growth factor 23; FGF-23; Osteoprotegerin; OPG; Peripheral artery disease; PAD; Critical limb ischemia; CLI; VASCULAR CALCIFICATION; CAROTID PLAQUE; OSTEOPROTEGERIN; MORTALITY; HEART; NEPHROPATHY; ASSOCIATION; METABOLISM; EXPRESSION; PROTEIN;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: Fibroblast growth factor 23 (FGF23) was demonstrated to be involved in the occurrence and development of cardiovascular disease (CVD). The aim of this study was to investigate the potential role of FGF23 on presence and severity of peripheral arterial disease (PAD) in type 2 diabetic patients. PATIENTS AND METHODS: In this study, we analyzed FGF23 serum levels in 413 type 2 diabetic patients with PAD and in 598 diabetic controls without lower limbs atherosclerosis. RESULTS: We found that FGF23 median serum levels were significantly higher in patients than in diabetic controls (69.3 (58.8-75.1) pg/mL in PAD and 42.98 (37.1-49.8) pg/mL in subjects without PAD (p < 0.001) and were significantly and independently associated with critical limb ischemia (CLI) [OR, 7.69 (2.64-16.31); p = 0.001]. CONCLUSIONS: We have found, for the first time, that FGF23 could be associated with presence and severity of PAD in Italian patients with type 2 diabetes.
引用
收藏
页码：4048 / 4054
页数：7
相关论文
共 50 条
  • [1] Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects
    Giovannini, Silvia
    Tinelli, Giovanni
    Biscetti, Federico
    Straface, Giuseppe
    Angelini, Flavia
    Pitocco, Dario
    Mucci, Luciana
    Landolfi, Raffaele
    Flex, Andrea
    CARDIOVASCULAR DIABETOLOGY, 2017, 16
  • [2] Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis
    Biscetti, Federico
    Straface, Giuseppe
    Porreca, Carlo Filippo
    Bertoletti, Giovanni
    Vincenzoni, Claudio
    Snider, Francesco
    Stigliano, Egidio
    Arena, Vincenzo
    Angelini, Flavia
    Pecorini, Giovanni
    Bianchi, Antonio
    Landolfi, Raffaele
    Flex, Andrea
    CARDIOVASCULAR DIABETOLOGY, 2015, 14
  • [3] Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects
    Silvia Giovannini
    Giovanni Tinelli
    Federico Biscetti
    Giuseppe Straface
    Flavia Angelini
    Dario Pitocco
    Luciana Mucci
    Raffaele Landolfi
    Andrea Flex
    Cardiovascular Diabetology, 16
  • [4] Assessment of fibroblast growth factor 23 in relation to peripheral arterial disease in type 2 diabetes mellitus
    Mohamed R. Halawa
    Abeer A. Abdalah
    Yara M. Eid
    Merhan S. Nasr
    Bassem M. Mostafa
    Nesma H. Ahmed
    The Egyptian Journal of Internal Medicine, 2019, 31 (4) : 902 - 907
  • [5] Association of serum Cyr61 levels with peripheral arterial disease in subjects with type 2 diabetes
    Feng, Bin
    Xu, Guidong
    Sun, Kangyun
    Duan, Kaipeng
    Shi, Bimin
    Zhang, Nannan
    CARDIOVASCULAR DIABETOLOGY, 2020, 19 (01)
  • [6] Epidemiology of Peripheral Arterial Disease and Critical Limb Ischemia
    Dua, Anahita
    Lee, Cheong J.
    TECHNIQUES IN VASCULAR AND INTERVENTIONAL RADIOLOGY, 2016, 19 (02) : 91 - 95
  • [7] Positive correlation of serum fibroblast growth factor 23 with peripheral arterial stiffness in kidney transplantation patients
    Liu, Yao-Chang
    Tsai, Jen-Pi
    Wang, Li-Hsuan
    Lee, Ming-Che
    Hsu, Bang-Gee
    CLINICA CHIMICA ACTA, 2020, 505 : 9 - 14
  • [8] Multidisciplinary Treatment for Critical Limb Ischemia in Peripheral Arterial Disease
    Komai, Hiroyoshi
    ANNALS OF VASCULAR DISEASES, 2019, 12 (02) : 151 - 156
  • [9] SERUM LEVELS OF FIBROBLAST GROWTH FACTOR 21 IN TYPE 2 DIABETIC PATIENTS
    Panahi, Y.
    Bonakdaran, S.
    Yaghoubi, M. A.
    Keramati, M. R.
    Haratian, M.
    Sahebkar, A.
    ACTA ENDOCRINOLOGICA-BUCHAREST, 2016, 12 (03) : 257 - 261
  • [10] Graz Critical Limb Ischemia Score: A Risk Score for Critical Limb Ischemia in Peripheral Arterial Occlusive Disease
    Gary, Thomas
    Belaj, Klara
    Hafner, Franz
    Eller, Philipp
    Rief, Peter
    Hackl, Gerald
    Brodmann, Marianne
    MEDICINE, 2015, 94 (27) : e1054
12345