Four new compounds from the roots of Euphorbia ebracteolata and their inhibitory effect on LPS-induced NO production

被引：14

作者：

Bai, Jiao ^{[1
,2
]}

Huang, Xue-Yan ^{[1
,2
]}

Liu, Zhi-Guo ^{[1
,2
]}

Gong, Chi ^{[1
,2
]}

Li, Xin-Yu ^{[1
,2
]}

Li, Da-Hong ^{[1
,2
]}

Hua, Hui-Ming ^{[1
,2
]}

Li, Zhan-Lin ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China

来源：

FITOTERAPIA | 2018年 / 125卷

基金：

中国国家自然科学基金;

关键词：

Euphorbia ebracteolata; Diterpenoids; Sesquiterpenes; Anti-inflammation; CHEMICAL-CONSTITUENTS; ROSANE DITERPENES; FISCHERIANA; DERIVATIVES; HAYATA;

D O I：

10.1016/j.fitote.2017.12.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new diterpenoids, ebractenoids O similar to Q (1-3), and a new phenolic glucoside, gamma-pyrone-3-O-beta-D-(6-galloyl)glucopyranoside (4), together with 6 known compounds, were isolated from the 95% ethanol extract of the roots of Euphorbia ebracteolata, and their structures were elucidated on the basis of spectroscopic data. The absolute configurations of 1-3 were determined by electronic circular dichroism (ECD) calculations. The inhibitory effects of all the isolates with exception of compounds 8 and 10 on the NO production in lipopolysaccharide (LPS)induced macrophages were evaluated. All of them exhibited significant inhibitory activity.

引用

页码：235 / 239

页数：5

共 28 条

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