Trichlorosilyl triflate-mediated enantioselective directed cross-aldol reaction between ketones using a chiral phosphine oxide as an organocatalyst

被引：27

作者：

Aoki, Shohei ^{[2
]}

Kotani, Shunsuke ^{[1
]}

Sugiura, Masaharu ^{[2
]}

Nakajima, Makoto ^{[2
]}

机构：

[1] Kumamoto Univ, Prior Org Innovat & Excellence, Chuo Ku, Kumamoto, Japan

[2] Kumamoto Univ, Grad Sch Pharmaceut Sci, Chuo Ku, Kumamoto, Japan

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 44期

关键词：

QUATERNARY CARBON CENTERS; TERTIARY ALCOHOLS; CLAISEN CONDENSATION; CONJUGATE REDUCTION; AMINO-ALCOHOLS; CONSTRUCTION; ALDEHYDES; STEREOCENTERS; ESTERS; ADDITIONS;

D O I：

10.1039/c2cc31543b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Trichlorosilyl triflate-promoted directed cross-aldol reaction between ketones in the presence of a chiral phosphine oxide as an organocatalyst is described. This is the first enantioselective cross-aldol reaction between simple ketones with good enantioselectivity.

引用

页码：5524 / 5526

页数：3

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