Deceased donor kidneys are discarded at higher rates when labeled as high kidney donor profile index

被引:17
作者
Crannell, William Christian [1 ]
Perkins, James D. [1 ,2 ]
Leca, Nicolae [3 ]
Kling, Catherine E. [1 ,2 ]
机构
[1] Univ Washington, Dept Surg, Div Transplant Surg, Seattle, WA 98195 USA
[2] Univ Washington, Clin & Bioanalyt Transplant Lab CBATL, Seattle, WA 98195 USA
[3] Univ Washington, Dept Med, Div Nephrol, Seattle, WA 98195 USA
关键词
clinical research/practice; donors and donation: extended criteria; ethics and public policy; graft survival; kidney transplantation/nephrology; organ acceptance; organ allocation; organ procurement and allocation;
D O I
10.1111/ajt.17197
中图分类号
R61 [外科手术学];
学科分类号
摘要
The kidney donor risk index (KDRI) and percentile conversion, kidney donor profile index (KDPI), provide a continuous measure of donor quality. Kidneys with a KDPI >85% (KDPI85) are referred to as "high KDPI." The KDPI85 cutoff changes every year, impacting which kidneys are labeled as KDPIHIGH. We examine kidney utilization around the KDPI85 cutoff and explore the "high KDPI" labeling effect. KDRI to KDPI Mapping Tables from 2012 to 2020 were used to determine the yearly KDRI85 value. Organ Procurement and Transplantation Network data was used to calculate discard rates and model organ use. KDRI85 varied between 1.768 and 1.888. In a multivariable analysis, kidney utilization was lower for KDPI 86% compared with KDPI 85% kidneys (p = .046). Kidneys with a KDRI between 1.785-1.849 were classified as KDPIHIGH in the years 2015-2017 and KDPILOW in the years 2018-2020. The discard rate was 44.9% when labeled as KDPIHIGH and 39.1% when labeled as KDPILOW (p <.01). For kidneys with the same KDRI, the high KDPI label is associated with increased discard. We should reconsider the appropriateness of the "high KDPI" label.
引用
收藏
页码:3087 / 3092
页数:6
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