How amyloid, sleep and memory connect

被引：42
作者：
Lucey, Brendan P. [1 ]
Holtzman, David M. [1 ]
机构：
[1] Washington Univ, Hope Ctr Neurol Disorders, Knight Alzheimers Dis Res Ctr, Dept Neurol, St Louis, MO 63130 USA
来源：
NATURE NEUROSCIENCE | 2015年 / 18卷 / 07期
关键词：
NREM SLOW WAVES; DEPENDENT MEMORY; BETA DYNAMICS; DEPOSITION; NETWORK; OREXIN;
D O I：
10.1038/nn.4048
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In a bidirectional relationship, the sleep/wake cycle regulates amyloid-b (Ab) levels and Ab accumulation then disrupts sleep. A quantitative three-way model now suggests that Ab impairs memory via its effect on sleep.
引用
收藏
页码：933 / 934
页数：3
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