Development of a Scalable Process for the Crop Protection Agent Isoclast

被引：57

作者：

Arndt, Kim E. ^{[2
]}

Bland, Douglas C. ^{[1
]}

Irvine, Nicholas M. ^{[2
]}

Powers, Stacey L. ^{[1
]}

Martin, Timothy P. ^{[2
]}

McConnell, James Russell ^{[1
]}

Podhorez, David E. ^{[1
]}

Renga, James M. ^{[2
]}

Ross, Ronald ^{[2
]}

Roth, Gary A. ^{[1
]}

Scherzer, Brian D. ^{[1
]}

Toyzan, Todd W. ^{[1
]}

机构：

[1] Dow Chem Co USA, Midland, MI 48674 USA

[2] Dow AgroSci LLC, Proc Chem, Indianapolis, IN 46268 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2015年 / 19卷 / 03期

关键词：

SULFILIMINES;

D O I：

10.1021/acs.oprd.5b00007

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A scalable process to the insecticide Isoclast manufactured by Dow AgroSciences LLC is described. The process involves the de novo construction of a fully elaborated pyridine sulfide using enamine-mediated cyclization followed by two efficient and inexpensive oxidations to introduce the sulfoximine.

引用

页码：454 / 462

页数：9

共 23 条

[1]

Arndt K. E., 2009, US Patent, Patent No. [7,511,149 B2, 7511149]

[2] METHYLTHIOMETHYLATION OF ANILINES AND PHENOLS .9. N-ARYL SULFIMIDES [J].