An easy-to-use heterogeneous catalyst for the Knoevenagel condensation

被引：26

作者：

Siebenhaar, B ^{[1
]}

Casagrande, B ^{[1
]}

Studer, M ^{[1
]}

Blaser, HU ^{[1
]}

机构：

[1] Solvias AG, CH-4002 Basel, Switzerland

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 2001年 / 79卷 / 5-6期

关键词：

Knoevenagel condensation; solid basic catalysts; zeolite-sodium carbonate mixtures;

D O I：

10.1139/cjc-79-5-6-566

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Physical mixtures of alkali and earth alkali metal carbonates and commercially available zeolites were investigated as solid catalysts for the Knoevenagel condensation. Best results for the model reaction between benzaldehyde and ethyl cyanoacetate were obtained for a 1:4 mixture of Na2CO3 with 4 Angstrom molecular sieves (MS). The effects of the following parameters were investigated: structure of substrate, type and basicity of metal carbonate and zeolite, and temperature. Between 50 and 90 degreesC chemical yields up to >90% were obtained without continuous removal of water and with reasonable catalyst activities and reaction times. Na2CO3 - MS 4 Angstrom proved to be active for the condensation of several aldehydes and ketones with a variety of active methylene components.

引用

页码：566 / 569

页数：4

共 16 条

[1] AMINO-GROUPS IMMOBILIZED ON SILICA-GEL - AN EFFICIENT AND REUSABLE HETEROGENEOUS CATALYST FOR THE KNOEVENAGEL CONDENSATION [J].