Tough love

被引：0
|
作者：
Levinson, Randy
Lopez, Juan Carlos
Schubert, Charlotte
Speert, Debra
Stevens, Katherine
机构：
来源：
NATURE MEDICINE | 2008年 / 14卷 / 05期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A protein produced by Salmonella enterica-a leading cause of food-borne diseases, acts unexpectedly to counteract the bacteria's virulence. Protein secretion is crucial for the virulence of many pathogens, including Salmonella. A pathway- ZirTS was identified that consists of a secreted protein (ZirS) and its membrane translocator-ZirT. Inactivating ZirTS resulted in hypervirulent bacteria that could outcompete wild-type Salmonella in co-infection experiments. ZirTS functions as an antivirulence modulator remains to be established.
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页码：493 / 493
页数：1
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