Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

被引：117
作者：
Chiu, Tim T. [1 ,2 ]
Jensen, Thomas E. [1 ]
Sylow, Lykke [3 ]
Richter, Erik A. [3 ]
Klip, Amira [1 ]
机构：
[1] Hosp Sick Children, Cell Biol Program, Toronto, ON M5J 2L4, Canada
[2] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A1, Canada
[3] Univ Copenhagen, Dept Exercise & Sport Sci, Mol Physiol Grp, DK-1168 Copenhagen, Denmark
来源：
CELLULAR SIGNALLING | 2011年 / 23卷 / 10期
基金：
加拿大健康研究院; 英国医学研究理事会;
关键词：
Insulin signalling; Rac1; Actin; GLUT4; Skeletal muscle; PROTEIN-KINASE-C; INDUCED INSULIN-RESISTANCE; NUCLEOTIDE-EXCHANGE FACTOR; GTPASE-ACTIVATING PROTEIN; STIMULATED GLUT4 TRANSLOCATION; INDUCED GLUCOSE-TRANSPORT; CORTICAL ACTIN; RHO-GTPASES; PHOSPHATIDYLINOSITOL; 3-KINASE; CERAMIDE SYNTHESIS;
D O I：
10.1016/j.cellsig.2011.05.022
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：1546 / 1554
页数：9
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