Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

被引：117

作者：

Chiu, Tim T. ^{[1
,2
]}

Jensen, Thomas E. ^{[1
]}

Sylow, Lykke ^{[3
]}

Richter, Erik A. ^{[3
]}

Klip, Amira ^{[1
]}

机构：

[1] Hosp Sick Children, Cell Biol Program, Toronto, ON M5J 2L4, Canada

[2] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A1, Canada

[3] Univ Copenhagen, Dept Exercise & Sport Sci, Mol Physiol Grp, DK-1168 Copenhagen, Denmark

来源：

CELLULAR SIGNALLING | 2011年 / 23卷 / 10期

基金：

加拿大健康研究院; 英国医学研究理事会;

关键词：

Insulin signalling; Rac1; Actin; GLUT4; Skeletal muscle; PROTEIN-KINASE-C; INDUCED INSULIN-RESISTANCE; NUCLEOTIDE-EXCHANGE FACTOR; GTPASE-ACTIVATING PROTEIN; STIMULATED GLUT4 TRANSLOCATION; INDUCED GLUCOSE-TRANSPORT; CORTICAL ACTIN; RHO-GTPASES; PHOSPHATIDYLINOSITOL; 3-KINASE; CERAMIDE SYNTHESIS;

D O I：

10.1016/j.cellsig.2011.05.022

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1546 / 1554

页数：9

共 50 条

[1] Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice
Sylow, Lykke
Nielsen, Ida L.
Kleinert, Maximilian
Moller, Lisbeth L. V.
Ploug, Thorkil
Schjerling, Peter
Bilan, Philip J.
Klip, Amira
Jensen, Thomas E.
Richter, Erik A.
JOURNAL OF PHYSIOLOGY-LONDON, 2016, 594 (17): : 4997 - 5008
[2] EXERCISE, GLUT4, AND SKELETAL MUSCLE GLUCOSE UPTAKE
Richter, Erik A.
Hargreaves, Mark
PHYSIOLOGICAL REVIEWS, 2013, 93 (03) : 993 - 1017
[3] Role for RalA downstream of Rac1 in skeletal muscle insulin signalling
Takenaka, Nobuyuki
Sumi, Yukio
Matsuda, Keiko
Fujita, Junko
Hosooka, Tetsuya
Noguchi, Tetsuya
Aiba, Atsu
Satoh, Takaya
BIOCHEMICAL JOURNAL, 2015, 469 : 445 - 454
[4] Hydroxytyrosol modifies skeletal muscle GLUT4/AKT/Rac1 axis in trained rats
Casuso, Rafael A.
Al Fazazi, Saad
Ruiz-Ojeda, Francisco J.
Plaza-Diaz, Julio
Rueda-Robles, Ascension
Aragon-Vela, Jeronimo
Huertas, Jesus R.
JOURNAL OF CELLULAR PHYSIOLOGY, 2021, 236 (01) : 489 - 494
[5] A critical role of the small GTPase Rac1 in Akt2-mediated GLUT4 translocation in mouse skeletal muscle
Takenaka, Nobuyuki
Izawa, Rumi
Wu, Junyuan
Kitagawa, Kaho
Nihata, Yuma
Hosooka, Tetsuya
Noguchi, Tetsuya
Ogawa, Wataru
Aiba, Atsu
Satoh, Takaya
FEBS JOURNAL, 2014, 281 (05) : 1493 - 1504
[6] A critical role for the small GTPase Rac1 in insulin signaling that regulates glucose uptake in skeletal muscle
Satoh, Takaya
Takenaka, Nobuyuki
RESEARCH ON CHEMICAL INTERMEDIATES, 2019, 45 (11) : 5389 - 5397
[7] Rac1 Is a Novel Regulator of Contraction-Stimulated Glucose Uptake in Skeletal Muscle
Sylow, Lykke
Jensen, Thomas E.
Kleinert, Maximilian
Mouatt, Joshua R.
Maarbjerg, Stine J.
Jeppesen, Jacob
Prats, Clara
Chiu, Tim T.
Boguslavsky, Shlomit
Klip, Amira
Schjerling, Peter
Richter, Erik A.
DIABETES, 2013, 62 (04) : 1139 - 1151
[8] Cellular Regulation of Glucose Uptake by Glucose Transporter GLUT4
Govers, Roland
ADVANCES IN CLINICAL CHEMISTRY, VOL 66, 2014, 66 : 173 - 240
[9] Normal muscle glucose uptake in mice deficient in muscle GLUT4
Fam, Barbara C.
Rose, Laura J.
Sgambellone, Rebecca
Ruan, Zheng
Proietto, Joseph
Andrikopoulos, Sofianos
JOURNAL OF ENDOCRINOLOGY, 2012, 214 (03) : 313 - 327
[10] Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues
Rudich, A
Konrad, D
Török, D
Ben-Romano, R
Huang, C
Niu, W
Garg, RR
Wijesekara, N
Germinario, RJ
Bilan, PJ
Klip, A
DIABETOLOGIA, 2003, 46 (05) : 649 - 658

← 1 2 3 4 5 →