Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

被引：119

作者：

Chiu, Tim T. ^{[1
,2
]}

Jensen, Thomas E. ^{[1
]}

Sylow, Lykke ^{[3
]}

Richter, Erik A. ^{[3
]}

Klip, Amira ^{[1
]}

机构：

[1] Hosp Sick Children, Cell Biol Program, Toronto, ON M5J 2L4, Canada

[2] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A1, Canada

[3] Univ Copenhagen, Dept Exercise & Sport Sci, Mol Physiol Grp, DK-1168 Copenhagen, Denmark

来源：

CELLULAR SIGNALLING | 2011年 / 23卷 / 10期

基金：

加拿大健康研究院; 英国医学研究理事会;

关键词：

Insulin signalling; Rac1; Actin; GLUT4; Skeletal muscle; PROTEIN-KINASE-C; INDUCED INSULIN-RESISTANCE; NUCLEOTIDE-EXCHANGE FACTOR; GTPASE-ACTIVATING PROTEIN; STIMULATED GLUT4 TRANSLOCATION; INDUCED GLUCOSE-TRANSPORT; CORTICAL ACTIN; RHO-GTPASES; PHOSPHATIDYLINOSITOL; 3-KINASE; CERAMIDE SYNTHESIS;

D O I：

10.1016/j.cellsig.2011.05.022

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1546 / 1554

页数：9

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