Multimodal imaging of the distal interphalangeal-joint synovio-entheseal complex in psoriatic arthritis (MIDAS): a cross-sectional study on the diagnostic accuracy of different imaging modalities comparing psoriatic arthritis to psoriasis and osteoarthritis

被引：5

作者：

Guldberg-Moller, Jorgen ^{[1
,2
]}

Mogensen, Mette ^{[3
]}

Ellegaard, Karen ^{[1
]}

Zavareh, Ali ^{[4
]}

Wakefield, Richard J. ^{[5
]}

Tan, Ai Lyn ^{[5
]}

Boesen, Mikael ^{[6
]}

Dehmeshki, Jamshid ^{[7
]}

Kubassova, Olga ^{[7
]}

Dreyer, Lene ^{[1
,8
]}

Henriksen, Marius ^{[1
]}

Kristensen, Lars Erik ^{[1
]}

机构：

[1] Parker Inst, Frederiksberg, Denmark

[2] Slagelse Hosp, Dept Rheumatol, Slagelse, Denmark

[3] Bispebjerg Hosp, Dept Dermatol, Copenhagen, Denmark

[4] Guys & St Thomas Hosp NHS Trust, Radiol Dept, London, England

[5] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England

[6] Bispebjerg Hosp, Dept Radiol, Copenhagen, Denmark

[7] IAG Image Anal Grp, London, England

[8] Aalborg Univ Hosp, Dept Rheumatol, Aalborg, North Denmark R, Denmark

来源：

RMD OPEN | 2022年 / 8卷 / 01期

关键词：

Psoriatic Arthritis; Magnetic Resonance Imaging; Ultrasonography; Osteoarthritis; HAND OSTEOARTHRITIS; NAIL; PREVALENCE; ENTHESITIS; INVOLVEMENT; SPONDYLOARTHRITIS; CLASSIFICATION; EPIDEMIOLOGY; INFLAMMATION; RELIABILITY;

D O I：

10.1136/rmdopen-2021-002109

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective Can ultrasound (US), MRI and X-ray applied to the distal interphalangeal (DIP)-joint and synovio-entheseal complex (SEC) discriminate between patients with psoriatic arthritis (PsA), skin psoriasis (PsO) and hand osteoarthritis (OA)? Methods In this prospective, cross-sectional study, patients with DIP-joint PsA and nail involvement (n=50), PsO with nail involvement (n=12); and OA (n=13); were consecutively recruited. Risk ratios (RR) were calculated for US, MRI and X-ray findings of the DIP-joint and SEC between diagnoses. Results New bone formation (NBF) in US and MRI was a hallmark of OA, reducing the risk of having PsA (RR 0.52 (95% CI 0.43 to 0.63) and 0.64 (95% CI 0.56 to 0.74). The OA group was different from PsA and PsO on all MRI and X-ray outcomes reflected in a lower RR of having PsA; RR ranging from 0.20 (95% CI 0.13 to 0.31) for MRI bone marrow oedema (BMO) to 0.85 (95% CI 0.80 to 0.90) in X-ray enthesitis. No outcome in US, MRI or X-ray was significantly associated with a higher risk of PsA versus PsO, although there was a trend to a higher degree of US erosions and NBF in PsA. 82% of PsA and 67% of PsO was treated with disease modifying antirheumatic drugs which commonly reflects the clinical setting. Conclusion High grade of US, MRI and X-ray NBF reduce the RR of having PsA compared with OA. In PsA versus PsO patients, there was a trend for US to demonstrate more structural changes in PsA although this did not reach significance.

引用

页数：10