Phosphorylation of filamin (ABP-280) regulates the binding to the lipid membrane, integrin, and actin

被引：9

作者：

Goldmann, WH

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp, Dept Pathol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Childrens Hosp, Dept Surg, Boston, MA 02115 USA

来源：

CELL BIOLOGY INTERNATIONAL | 2001年 / 25卷 / 08期

关键词：

tyrosine phosphorylation; filamin (ABP-280); actin; integrin; lipid membrane;

D O I：

10.1006/cbir.2000.0710

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Actin-binding protein (ABP-280: filamin) is a phosphoprotein present in the periphery of the cytoplasm, where it can cross-link actin filaments, associate with lipid membranes, and bind to membrane surface receptors. Given its function and localization in the cell, the hypothesis that it serves as a substrate for p56(lek), a lymphocyte-specific member of the src family of protein tyrosine kinases associated with cell surface glycoproteins is considered. The results suggest conformationally-induced regulation of filamin (ABP-280). (C) 2001 Academic Press.

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收藏

页码：805 / 808

页数：4

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