Analysis of fatty acid, and lipoprotein, metabolism by GC and HPLC:: Effect of low-density lipoprotein apheresis

被引：2
作者：
Bláha, V
Solichová, D
Bláha, M
Havel, E
Pivokonska, M
Zadák, Z
机构：
[1] Charles Univ, Med Sch & Teaching Hosp, Dept Metab Care, Hradec Kralove 50005, Czech Republic
[2] Charles Univ, Med Sch & Teaching Hosp, Dept Haematol, Hradec Kralove 50005, Czech Republic
来源：
MIKROCHIMICA ACTA | 2001年 / 136卷 / 1-2期
关键词：
fatty acids; lipoprotein metabolism; atherosclerosis; hypercholesterolemia; LDL-apheresis;
D O I：
10.1007/s006040170062
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Blood samples from 5 hyperlipidemic patients on chronic treatment with low-density lipoprotein (LDL)- apheresis were analysed for lipids and fatty acids in serum, lipoprotein fractions and erythrocyte membrane by capillary gas chromatography (GC), reversed-phase high-performance liquid chromatography (LC), spectrofluorometry and spectrophotometry. LDL-apheresis has been associated with significant changes of fatty acids metabolism in relation to triglyceride-rich lipoproteins. Oleic acid may exert its hypo-triglyceridemic effect via VLDL, IDL, LDL and HDL Fractions. Polyunsaturated fatty acids, associated with triglyceride metabolism via IDL or VLDL, are linoleic, gamma-linolenic and docosahexaenoic fatty acids.
引用
收藏
页码：23 / 29
页数：7
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