Specificity and Negative Cooperativity in Dendrimer-Oxime Drug Complexation

被引：28

作者：

Choi, Seok Ki ^{[1
,2
]}

Leroueil, Pascale ^{[1
,2
]}

Li, Ming-Hsin ^{[1
,2
,3
]}

Desai, Ankur ^{[1
,2
]}

Zong, Hong ^{[1
,2
]}

Van der Spek, Abraham F. L. ^{[1
,2
,4
]}

Baker, James R., Jr. ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Michigan Nanotechnol Inst Med & Biol Sci, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USA

来源：

MACROMOLECULES | 2011年 / 44卷 / 11期

关键词：

HOST-GUEST CHEMISTRY; PAMAM DENDRIMERS; POLY(AMIDOAMINE) DENDRIMERS; AQUEOUS-SOLUTIONS; CATALYSIS; BIOMIMETICS; DELIVERY; BINDING; SIZE; IGM;

D O I：

10.1021/ma200522m

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A useful new insight in host-guest interactions of PAMAM (poly-(amidoamine)) dendrimers as a synthetic multivalent receptor was reported. 1H NMR titration experiments to locate structural determinants for the complex formation between a generation 5 (G5) PAMAM dendrimer and 2-PAM were performed. Upon the addition of 2-PAM, only a few subsets of the dendrimer protons that belong to terminal branches apparently shifted downfield as a function of the [2-PAM]/[D] ratio, while other inner protons remained almost unchanged. The relative magnitudes of such changes suggest that binding of the guest molecules selectively occurs at the terminal branches of the dendrimer. Furthermore, the 1H NMR titration experiments performed with N-methylpyridinium chloride (MPC), a molecule that lacks such an aldoxime moiety, under otherwise an identical condition led to no evidence for the complexation. The number of bound oxime molecules increases as a function of the ratio [oxime]/[D].

引用

页码：4026 / 4029

页数：4

共 29 条

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