Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation

被引：28

作者：

Martinez-Martinez, Ernesto ^{[1
]}

Cachofeiro, Victoria ^{[2
]}

Rousseau, Elodie ^{[3
,4
]}

Alvarez, Virginia ^{[1
,5
]}

Calvier, Laurent ^{[3
,4
]}

Fernandez-Celis, Amaya ^{[1
]}

Leroy, Celine ^{[3
,4
]}

Miana, Maria ^{[2
]}

Jurado-Lopez, Raquel ^{[2
]}

Briones, Ana M. ^{[6
]}

Jaisser, Frederic ^{[3
,4
,7
]}

Zannad, Faiez ^{[3
,4
]}

Rossignol, Patrick ^{[3
,4
]}

Lopez-Andres, Natalia ^{[1
,3
,4
]}

机构：

[1] NavarraBiomed Miguel Servet Fdn, Cardiovasc Translat Res, Pamplona 31008, Spain

[2] Univ Complutense, Dept Physiol, Sch Med, Inst Invest Sanitaria Gregorio Maranon IiSGM, E-28040 Madrid, Spain

[3] Univ Lorraine, UMR 1116, INSERM, Ctr Invest Clin Plurithemat 1433, Vandoeuvre Les Nancy, France

[4] CHU Nancy, Vandoeuvre Les Nancy, France

[5] Hosp Navarra, Heart Area, Pamplona, Spain

[6] Univ Autonoma Madrid, Dept Pharmacol, E-28049 Madrid, Spain

[7] Univ Paris 06, Ctr Rech Cordeliers, INSERM, UMR Team 1 872, Paris, France

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2015年 / 411卷 / 0C期

关键词：

Adipocyte differentiation; Adipose tissue; Aldosterone; IL-33/ST2; system; ADIPOSE-TISSUE; MINERALOCORTICOID RECEPTOR; INSULIN-RESISTANCE; ST2; OBESITY; EXPRESSION; PROTEIN; CELLS; OSTEOPONTIN; ADIPONECTIN;

D O I：

10.1016/j.mce.2015.04.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interleukin-33 (IL-33) but not soluble ST2 (sST2) exerts anti-inflammatory and protective effects in several tissues. Aldosterone, a proinflammatory mediator which promotes adipogenesis, is elevated in obese patients. The aim of this study was to investigate the interactions between IL-33/ST2 system and Aldosterone in adipose tissue. Rats fed a high fat diet presented increased sST2 expression, diminished IL-33/5ST2 ratio and enhanced levels of differentiation and inflammation in adipose tissue as compared to controls. A similar pattern was observed in adipose tissue from C57BL/6 Aldosterone-treated mice. In both animal models, Aldosterone was correlated with sST2. Treatment of 3T3-L1 adipocytes with IL-33 delayed adipocyte differentiation diminished lipid accumulation and decreased inflammation. Aldosterone decreased IL-33 and increased sST2 expressions in differentiated adipocytes. Aldosterone-induced adipocyte differentiation and inflammation were blocked by IL-33 treatment, but sST2 did not exert any effects. The crosstalk between IL-33/ST2 and Aldosterone could be relevant in the metabolic consequences of obesity. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：20 / 27

页数：8

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