Merging photoredox with copper catalysis: decarboxylative difluoroacetylation of α,β-unsaturated carboxylic acids with ICF2CO2Et

被引：68
|
作者：
Zhang, Heng-Rui [1 ]
Chen, Dao-Qian [1 ]
Han, Ya-Ping [1 ]
Qiu, Yi-Feng [1 ]
Jin, Dong-Po [1 ]
Liu, Xue-Yuan [1 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 79期
基金：
美国国家科学基金会;
关键词：
DUAL CATALYSIS; MEDIATED DIFLUOROMETHYLATION; RECENT PROGRESS; LIGHT; ALKENES; FLUORINE; TRIFLUOROMETHYLATION; DIFLUOROALKYLATION; HYDRODIFLUOROMETHYLATION; FUNCTIONALIZATION;
D O I：
10.1039/c6cc06284a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A photoredox-/copper-catalyzed decarboxylative difluoroacetylation reaction of alpha,beta-unsaturated carboxylic acids has been developed. This reaction produces a variety of difluoroalkylated alkenes in moderate to excellent yields and exhibits satisfactory stereoselectivity and a broad substrate scope at ambient temperature. Furthermore, this decarboxylative difluoroacetylation protocol provides efficient and environment friendly access to the difluoroalkylated alkenes.
引用
收藏
页码：11827 / 11830
页数：4
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