Merging photoredox with copper catalysis: decarboxylative difluoroacetylation of α,β-unsaturated carboxylic acids with ICF2CO2Et

被引：68

作者：

Zhang, Heng-Rui ^{[1
]}

Chen, Dao-Qian ^{[1
]}

Han, Ya-Ping ^{[1
]}

Qiu, Yi-Feng ^{[1
]}

Jin, Dong-Po ^{[1
]}

Liu, Xue-Yuan ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 79期

基金：

美国国家科学基金会;

关键词：

DUAL CATALYSIS; MEDIATED DIFLUOROMETHYLATION; RECENT PROGRESS; LIGHT; ALKENES; FLUORINE; TRIFLUOROMETHYLATION; DIFLUOROALKYLATION; HYDRODIFLUOROMETHYLATION; FUNCTIONALIZATION;

D O I：

10.1039/c6cc06284a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A photoredox-/copper-catalyzed decarboxylative difluoroacetylation reaction of alpha,beta-unsaturated carboxylic acids has been developed. This reaction produces a variety of difluoroalkylated alkenes in moderate to excellent yields and exhibits satisfactory stereoselectivity and a broad substrate scope at ambient temperature. Furthermore, this decarboxylative difluoroacetylation protocol provides efficient and environment friendly access to the difluoroalkylated alkenes.

引用

页码：11827 / 11830

页数：4

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