Isolation of Talathermophilins from the Thermophilic Fungus Talaromyces thermophilus YM3-4

被引：43
作者：
Guo, Ji-Peng [1 ,2 ]
Tan, Jian-Lin [1 ,2 ]
Wang, Yan-Li [1 ,2 ]
Wu, Hong-Yang [1 ,2 ]
Zhang, Chuan-Ping [1 ,2 ]
Niu, Xue-Mei [1 ,2 ]
Pan, Wen-Zheng [1 ,2 ,3 ]
Huang, Xiao-Wei [1 ,2 ]
Zhang, Ke-Qin [1 ,2 ]
机构：
[1] Yunnan Univ, Lab Conservat & Utilizat Bioresources, Kunming 650091, Peoples R China
[2] Yunnan Univ, Key Lab Microbial Resources, Minist Educ, Kunming 650091, Peoples R China
[3] Yunnan Reascend Tobacco Technol Grp Co Ltd, Kunming 650106, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 10期
基金：
中国国家自然科学基金;
关键词：
PRENYLATED INDOLE ALKALOIDS; NONRIBOSOMAL PEPTIDE ANTIBIOTICS; BIOMIMETIC TOTAL-SYNTHESIS; MARINE-DERIVED FUNGUS; STEPHACIDIN-A; BIOSYNTHESIS; PARAHERQUAMIDES; CONFORMATIONS; TRANSFERASES; BREVIANAMIDE;
D O I：
10.1021/np200365z
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Six indole alkaloids with various levels of prenylation were isolated from the thermophilic fungus Talaromyces thermophilus strain YM3-4. Their structures were identified by NMR and MS spectroscopic analyses. Compounds 1 and 2 are new analogues of the key versatile precursor notoamide E. Compound 3 is a novel analogue of preechinulin, and compound 4 was reported as a natural occurring cyclo(glycyltryptophyl) for the first time. The metabolite profile of this thermophilic organism displayed a biosynthetic pathway for talathermophilins.
引用
收藏
页码：2278 / 2281
页数：4
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