Amyotrophic lateral sclerosis care and research in the United States during the COVID-19 pandemic: Challenges and opportunities

被引：42

作者：

Andrews, Jinsy A. ^{[1
]}

Berry, James D. ^{[2
]}

Baloh, Robert H. ^{[3
]}

Carberry, Nathan ^{[1
]}

Cudkowicz, Merit E. ^{[2
]}

Dedi, Brixhilda ^{[1
]}

Glass, Jonathan ^{[4
]}

Maragakis, Nicholas J. ^{[5
]}

Miller, Timothy M. ^{[6
]}

Paganoni, Sabrina ^{[2
]}

Rothstein, Jeffrey D. ^{[5
]}

Shefner, Jeremy M. ^{[7
]}

Simmons, Zachary ^{[8
]}

Weiss, Michael D. ^{[9
]}

Bedlack, Richard S. ^{[10
]}

机构：

[1] Columbia Univ, Neurol Inst, New York, NY USA

[2] Massachusetts Gen Hosp, Dept Neurol, Healey Ctr ALS, Boston, MA 02114 USA

[3] Cedars Sinai Med Ctr, Dept Neurol, Los Angeles, CA 90048 USA

[4] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA

[5] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[6] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[7] Barrow Neurol Inst, Phoenix, AZ 85013 USA

[8] Penn State Hlth Milton S Hershey Med Ctr, Neurol, Hershey, PA USA

[9] Univ Washington, Dept Neurol, Seattle, WA 98195 USA

[10] Duke Univ, Dept Neurol, Durham, NC USA

来源：

MUSCLE & NERVE | 2020年 / 62卷 / 02期

基金：

美国国家卫生研究院;

关键词：

amyotrophic lateral sclerosis; clinical care; clinical trials; COVID-19; pandemic; MULTIDISCIPLINARY ALS; TELEMEDICINE; DIAGNOSIS; SURVIVAL; CRITERIA;

D O I：

10.1002/mus.26989

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Coronavirus disease 2019 has created unprecedented challenges for amyotrophic lateral sclerosis (ALS) clinical care and research in the United States. Traditional evaluations for making an ALS diagnosis, measuring progression, and planning interventions rely on in-person visits that may now be unsafe or impossible. Evidence- and experience-based treatment options, such as multidisciplinary team care, feeding tubes, wheelchairs, home health, and hospice, have become more difficult to obtain and in some places are unavailable. In addition, the pandemic has impacted ALS clinical trials by impairing the ability to obtain measurements for trial eligibility, to monitor safety and efficacy outcomes, and to dispense study drug, as these also often rely on in-person visits. We review opportunities for overcoming some of these challenges through telemedicine and novel measurements. These can reoptimize ALS care and research in the current setting and during future events that may limit travel and face-to-face interactions.

引用

页码：182 / 186

页数：5

共 33 条

[1] Single-breath counting: a pilot study of a novel technique for measuring pulmonary function in children [J].