Positron emission tomography after fetal transplantation in Huntington's disease

被引：52

作者：

Furtado, S

Sossi, V

Hauser, RA

Samii, A

Schulzer, M

Murphy, CB

Freeman, TB

Stoessl, AJ

机构：

[1] Univ British Columbia, Vancouver Hosp & Hlth Sci Ctr, Pacific Parkinsons Res Ctr, Vancouver, BC V6T 2B5, Canada

[2] Univ S Florida, Dept Neurol, Tampa, FL 33620 USA

[3] Univ S Florida, Dept Neurosurg, Tampa, FL 33620 USA

来源：

ANNALS OF NEUROLOGY | 2005年 / 58卷 / 02期

关键词：

D O I：

10.1002/ana.20564

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Huntington's disease (HD) is a progressive disorder with no known cure. We report two-year postoperative positron emission tomography (PET) data from 7 HD patients who underwent intrastriatal fetal transplantation. Patients showed widespread reductions in glucose uptake with no significant change over 2 years. Dopamine receptor binding was significantly reduced in HD striatum. 131 binding did not change significantly following transplantation, but there was a significant loss of D2 binding. These findings may reflect loss of graft viability and/or disease progression. There was no significant relationship between changes in PET and clinical function. In summary, there was no benefit from transplantation.

引用

页码：331 / 337

页数：7

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