Potent and selective agonists of Sphingosine-1-Phosphate 1 (S1P1): The discovery and SAR of a novel isoxazole based series

被引:0
|
作者
Watterson, Scott H. [1 ]
Guo, Junqing [1 ]
Spergel, Steven H. [1 ]
Langevine, Charles M. [1 ]
Moquin, Robert V. [1 ]
Kempson, James [1 ]
Shen, Ding Ren [1 ]
Yarde, Melissa [1 ]
Cvijic, Mary Ellen [1 ]
Banas, Dana [1 ]
Liu, Richard [1 ]
Suchard, Suzanne J. [1 ]
Gillooly, Kathleen [1 ]
Taylor, Tracy [1 ]
Shuster, David J. [1 ]
RexRabe, Sandra [1 ]
McIntyre, Kim J. [1 ]
Cornelius, Georgia [1 ]
Darienzo, Celia [1 ]
Marino, Anthony [1 ]
Balimane, Praveen [1 ]
Saltercid, Luisa [1 ]
McKinnon, Murray [1 ]
Barrish, Joel C. [1 ]
Carter, Percy H. [1 ]
Pitts, William J. [1 ]
Xie, Jenny [1 ]
Dyckman, Alaric J. [1 ]
机构
[1] Bristol Myers Squibb Co, Res & Dev, Princeton, NJ USA
来源
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 241卷
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
96-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design
    Xiao, Hai-Yun
    Watterson, Scott H.
    Langevine, Charles M.
    Srivastava, Anurag S.
    Ko, Soo S.
    Zhang, Yanlei
    Cherney, Robert J.
    Guo, Wei-Wei
    Gilmore, John L.
    II, James E. Sheppeck
    Wu, Dauh-Rurng
    Li, Peng
    Ramasamy, Duraisamy
    Arunachalam, Piramanayagam
    Mathur, Arvind
    Taylor, Tracy L.
    Shuster, David J.
    McIntyre, Kim W.
    Shen, Ding-Ren
    Yarde, Melissa
    Cvijic, Mary Ellen
    Marino, Anthony M.
    Balimane, Praveen V.
    Yang, Zheng
    Banas, Dana M.
    Cornelius, Georgia
    D'Arienzo, Celia J.
    Warrack, Bethanne M.
    Lehman-McKeeman, Lois
    Salter-Cid, Luisa M.
    Xie, Jenny
    Barrish, Joel C.
    Carter, Percy H.
    Dyckman, Alaric J.
    Dhar, T. G. Murali
    JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (21) : 9837 - 9854
  • [22] Discovery of Novel 1,2,4-Thiadiazole Derivatives as Potent, Orally Active Agonists of Sphingosine 1-Phosphate Receptor Subtype 1 (S1P1)
    Ren, Feng
    Deng, Guanghui
    Wang, Hailong
    Luan, Linbo
    Meng, Qinghua
    Xu, Qiongfeng
    Xu, Heng
    Xu, Xuesong
    Zhang, Haibo
    Zhao, Baowei
    Li, Chengyong
    Guo, Taylor B.
    Yang, Jiansong
    Zhang, Wei
    Zhao, Yonggang
    Jia, Qiantao
    Lu, Hongtao
    Xiang, Jia-Ning
    Elliott, John D.
    Lin, Xichen
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (09) : 4286 - 4296
  • [23] Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists
    Aguilar, Nuria
    Mir, Marta
    Grima, Pedro M.
    Lopez, Manel
    Segarra, Victor
    Esteban, Laia
    Moreno, Imma
    Godessart, Nuria
    Tarrason, Gema
    Domenech, Teresa
    Vilella, Dolors
    Armengol, Clara
    Cordoba, Monica
    Sabate, Mar
    Casals, Daniel
    Dominguez, Maria
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (24) : 7672 - 7676
  • [24] Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists
    Meng, Qinghua
    Zhao, Baowei
    Xu, Qiongfeng
    Xu, Xuesong
    Deng, Guanghui
    Li, Chengyong
    Luan, Linbo
    Ren, Feng
    Wang, Hailong
    Xu, Heng
    Xu, Yan
    Zhang, Haibo
    Xiang, Jia-Ning
    Elliott, John D.
    Guo, Taylor B.
    Zhao, Yonggang
    Zhang, Wei
    Lu, Hongtao
    Lin, Xichen
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (08) : 2794 - 2797
  • [25] Discovery of AMG 369, a potent and selective thiazolo[5,4-b]pyridine agonist of sphingosine-1-phosphate receptors 1 and 5 (S1P1 and S1P5)
    Gee, Victor J.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
  • [26] Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes
    Yan, Lin
    Huo, Pei
    Doherty, George
    Toth, Lesile
    Hale, Jeffrey J.
    Mills, Sander G.
    Hajdu, Richard
    Keohane, Carol A.
    Rosenbach, Mark J.
    Milligan, James A.
    Shei, Gan-Ju
    Chrebet, Gary
    Bergstrom, James
    Card, Deborah
    Quackenbush, Elizabeth
    Wickham, Alexandra
    Mandala, Suzanne M.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (14) : 3679 - 3683
  • [27] Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: Analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog (vol 77, pg 1011, 2009)
    Yonesu, Kiyoaki
    Kawase, Yumi
    Inoue, Tatsuya
    Takagi, Nana
    Tsuchida, Jun
    Takuwa, Yoh
    Kumakura, Seiichiro
    Nara, Futoshi
    BIOCHEMICAL PHARMACOLOGY, 2010, 79 (07) : 1081 - 1082
  • [28] Pharmacophore-based design of novel oxadiazoles as selective sphingosine-1-phosphate (S1P) receptor agonists with in vivo efficacy
    Quattropani, Anna
    Sauer, Wolfgang
    Crosignani, Stefano
    Dorbais, Jerome
    Gerber, Patrick
    Gonzalez, Jerome
    Marin, Delphine
    Muzerelle, Mathilde
    Beltran, Fanny
    Nichols, Anthony
    Georgi, Katrin
    Schneider, Manfred
    Vitte, Pierre-Alain
    Eligert, Valerie
    Novo-Perez, Laurence
    Hantson, Jennifer
    Nock, Sebastien
    Carboni, Susanna
    de Souza, Adriano Soares
    Arrighi, Jean-Francois
    Boschert, Ursula
    Bombrun, Agnes
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
  • [29] Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate:: Discovery of potent S1P receptor agonists
    Clemens, JJ
    Davis, MD
    Lynch, KR
    Macdonald, TL
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (20) : 3401 - 3404
  • [30] Pharmacophore-Based Design of Novel Oxadiazoles as Selective Sphingosine-1-phosphate (S1P) Receptor Agonists with in vivo Efficacy
    Quattropani, Anna
    Sauer, Wolfgang H. B.
    Crosignani, Stefano
    Dorbais, Jerome
    Gerber, Patrick
    Gonzalez, Jerome
    Marin, Delphine
    Muzerelle, Mathilde
    Beltran, Fanny
    Nichols, Anthony
    Georgi, Katrin
    Schneider, Manfred
    Vitte, Pierre-Alain
    Eligert, Valerie
    Novo-Perez, Laurence
    Hantson, Jennifer
    Nock, Sebastien
    Carboni, Susanna
    de Souza, Adriano Luis Soares
    Arrighi, Jean-Francois
    Boschert, Ursula
    Bombrun, Agnes
    CHEMMEDCHEM, 2015, 10 (04) : 688 - 714