Transcriptional regulation of Treg homeostasis and functional specification

被引：17
作者：
Wang, Ke [1 ]
Fu, Wenxian [1 ,2 ]
机构：
[1] Univ Calif San Diego, Dept Pediat, Pediat Diabet Res Ctr, 9500 Gilman Dr, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Moores Canc Ctr, 9500 Gilman Dr, La Jolla, CA 92093 USA
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2020年 / 77卷 / 21期
关键词：
Treg; Homeostasis; TCF1; LEF1; Precursor; Cofactor; T-CELL DEVELOPMENT; NF-KAPPA-B; LOW-DOSE INTERLEUKIN-2; SUPPRESSIVE FUNCTION; FOXP3; EXPRESSION; C-REL; GENE-EXPRESSION; TUMOR-IMMUNITY; ADIPOSE-TISSUE; THYMIC DEVELOPMENT;
D O I：
10.1007/s00018-020-03534-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
CD4(+)Foxp3(+) regulatory T (Treg) cells are key players in keeping excessive inflammation in check. Mounting evidence has shown that Treg cells exert much more diverse functions in both immunological and non-immunological processes. The development, maintenance and functional specification of Treg cells are regulated by multilayered factors, including antigens and TCR signaling, cytokines, epigenetic modifiers and transcription factors (TFs). In the review, we will focus on TFs by summarizing their unique and redundant roles in Treg cells under physiological and pathophysiological conditions. We will also discuss the recent advances of Treg trajectories between lymphoid organs and non-lymphoid tissues. This review will provide an updated view of the newly identified TFs and new functions of known TFs in Treg biology.
引用
收藏
页码：4269 / 4287
页数：19
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